高纯度人绝经期促性腺激素对不同年龄卵巢储备功能正常不孕患者体外受精-胚胎移植结局的影响  

Effect of highly purified human menopausal gonadotrophin on outcomes of in vitro fertilization-embryo transfer in infertile patients with normal ovarian reserve at different ages

作　　者：赵海君[1] 张皙卉 卢静[1] 张一娇 王玉红[1] 陈静[1] 景丽 常月婷 常文亮[1] ZHAO Haijun;ZHANG Xihui;LU Jing;ZHANG Yijiao;WANG Yuhong;CHEN Jing;JING Li;CHANG Yueting;CHANG Wenliang(Department of Reproductive Medicine,Handan Central Hospital,Handan 056000,Hebei Province,China;The Second Department of Gynecology,the Fourth Hospital of Shijiazhuang,Shijiazhuang 050000,Hebei Province,China)

机构地区：[1]邯郸市中心医院生殖医学科,河北邯郸056000 [2]石家庄市第四医院妇二科,河北石家庄050000

出　　处：《新乡医学院学报》2022年第6期544-547,共4页Journal of Xinxiang Medical University

基　　金：河北省科学技术厅健康医疗与生物医药专项(编号:182777197);邯郸市科学技术厅资助项目(编号:19422083009-7)。

摘　　要：目的探讨高纯度人绝经期促性腺激素(HP-HMG)对不同年龄卵巢储备功能正常不孕患者体外受精-胚胎移植(IVF-ET)结局的影响。方法回顾性分析2015年6月至2019年12月在邯郸市中心医院采用HP-HMG促排卵行IVF-ET助孕的127例患者的临床资料,根据年龄将患者分为低龄组(<35岁,n=63)和高龄组(≥35岁,n=64)。比较2组患者促排卵指标和实验室及移植后临床结局指标。结果2组患者的促性腺激素(Gn)用量、人绒毛膜促性腺激素(HCG)注射日雌二醇水平、HCG注射日黄体生成素水平、HCG注射孕酮水平、第Ⅱ次减数分裂中期卵数、可利用胚胎数、临床妊娠率、胚胎种植率及流产率比较差异均无统计学意义(P>0.05)。高龄组患者Gn使用时间和获卵数显著少于低龄组,优质胚胎率显著高于低龄组(P<0.05)。结论HP-HMG促排卵有助于提高高龄卵巢储备功能正常不孕患者优质胚胎率,改善IVF-ET妊娠结局。Objective To investigate the effect of highly purified human menopausal gonadotropin(HP-HMG)on outcomes of in vitro fertilization-embryo transfer(IVF-ET)of infertile patients with normal ovarian reserve at different ages.Methods The clinical data of 127 patients who received HP-HMG ovulation induction for IVF-ET in Handan Central Hospital from June 2015 to December 2019 were retrospectively analyzed.The patients were divided into younger group(<35 years old,n=63)and older group(≥35 years old,n=64)according to the age.The ovulation induction indicators,laboratory indexes and post transplant clinical outcomes of patients were analyzed between the two groups.Results There was no significant difference in the gonadotrophin(Gn)dosage,estrogen level on the human chorionic gonadotropin(HCG)injection day,luteinizing hormone level on the HCG injection day,progesterone level on the HCG injection day,the number of ovums in meiosis metaphaseⅡ,the number of available embryos,clinical pregnancy rate,embryo implantation rate and abortion rate of patients between the two groups(P>0.05).The Gn usage time and the number of obtaining ovums of patients in the elder group were significantly lower than those in the younger group,while the rate of high-quality embryos was significantly higher than that in the younger group(P<0.05).Conclusion HP-HMG ovulation induction is helpful to improve the high-quality embryos rate of elderly infertile patients with normal ovarian reserve and improve the pregnancy outcome of IVF-ET.

关 键 词：高纯度人绝经期促性腺激素 不孕症 体外受精 胚胎移植 

分 类 号：R715.2[医药卫生—妇产科学]