维生素K对2型糖尿病作用机制的研究进展  

Study progress on the mechanism of Vitamin K on type 2 diabetes mellitus

作　　者：郭安然 刘秀香 GUO Anran;LIU XiuXiang(Neonatal Intensive Care Unit,Women and Children’s Hospital of Qingdao University,Shangdong Province,Qingdao 266034,China)

机构地区：[1]青岛大学附属妇女儿童医院新生儿重症监护室,山东青岛266034

出　　处：《中国医药导报》2022年第16期34-37,共4页China Medical Herald

基　　金：国家卫生健康委医药卫生科技发展研究中心课题(WA2020HK62);中华国际科学交流基金会项目(Z2021L SD004);国家卫生计生委医药卫生科技发展研究中心课题(W2015EAE078)。

摘　　要：2型糖尿病是全球关注的重大慢性疾病之一,其发病机制仍未完全阐明,是威胁人类健康的世界性公共卫生问题。维生素K是一类具有叶绿醌生物活性的萘醌基团衍生物,是维持最佳身体机能所必需的生物活性化合物,可参与维生素K依赖性蛋白的羧化过程,在防治骨质疏松症、动脉粥样硬化、减少炎症因子释放和提高胰岛素敏感性等方面有着积极作用。本文主要围绕维生素K对调节胰岛素敏感性和血糖状态的可能作用机制进行阐述,增加新的辅助治疗方法,从而更好地控制糖尿病的进展。Type 2 diabetes mellitus is one of the major chronic diseases of global concern.Its pathogenesis has not yet been fully elucidated.It is a worldwide public health problem threatening human health.Vitamin K is a kind of naphthoquinone derivative with phylloquinone biological activity.It is a biologically active compound necessary to maintain optimal body function.It can participate in the carboxylation process of Vitamin K dependent proteins,it plays a positive role in prerenting and treating atherosclerosis,reducing the release of inflammatory factors,and improving insulin sensitivity have a positive effect.This review focuses on the possible mechanism of Vitamin K in regulating insulin sensitivity and blood sugar status,adding new adjuvant treatments to better control the progress of diabetes.

关 键 词：维生素K 2型糖尿病 胰岛素抵抗 维生素K依赖性蛋白 炎症因子 

分 类 号：R58[医药卫生—内分泌]