CLCA1的功能及在疾病中的作用研究进展  

Research progress on the function and role of CLCA1 in diseases

作　　者：万胜君 柯昌斌[1] WAN Shengjun;KE Changbin(Department of Anesthesiology,Taihe Hospital,Hubei University of Medicine,Hubei Province,Shiyan 442000,China)

机构地区：[1]湖北医药学院附属太和医院麻醉科,湖北十堰442000

出　　处：《中国医药导报》2022年第16期38-41,45,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81971060);湖北医药学院研究生科技创新项目(YC2021040)。

摘　　要：钙激活氯通道调节剂1(CLCA1)是一种分泌型自催化裂解的蛋白质,属于CLCA家族的一员,它能够激活哺乳动物细胞中钙依赖的氯离子电流,并具有锌金属蛋白酶特性。通过发挥其金属蛋白酶和阴离子通道激活作用,CLCA1在呼吸系统和消化系统黏液高分泌相关疾病如支气管哮喘、溃疡性结肠炎的发病机制中起重要作用。同时,由于其上皮细胞氯离子及其他阴离子的传导调节作用而参与恶性肿瘤发生发展进程。本文就CLCA1的分子结构、相关特性以及与相关疾病的关系研究进展作一综述。Calcium-activated chloride channel regulator 1(CLCA1)is a secretory autocatalytic lysate protein,a member of the CLCA family,that activates calcium-dependent chloride currents in mammalian cells and has zinc metalloproteinase properties.Through its metalloproteinase and anion channel activation,CLCA1 plays an important role in the pathogenesis of mucus hypersecretion-related diseases of the respiratory and digestive systems,such as bronchial asthma and ulcerative colitis.At the same time,it is involved in the occurrence and development of malignant tumors due to the conduction regulation of chloridion and other anions in epithelial cells.In this review,the molecular structure,related properties and the relationship between CLCA1 and related diseases are reviewed.

关 键 词：钙激活氯通道调节剂1 钙激活氯通道 氯离子 黏液分泌 

分 类 号：R969[医药卫生—药理学]