慢性阻塞性肺疾病急性加重期患者一氧化氮与白细胞介素-17、肺功能相关性分析  

Correlation of fractional exhaled nitric oxide with interleukin-17 and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：刘水红[1] 甘明 陶凌凤[2] 李小玲[3] 刘剑荣 LIU Shuihong;GAN Ming;TAO Lingfeng;LI Xiaoling;LIU Jianrong(Department of Laboratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China;Pulmonary Function Test Room,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China;Department of Respiratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市人民医院检验科,江西萍乡337000 [2]江西省萍乡市人民医院肺功能检测室,江西萍乡337000 [3]江西省萍乡市人民医院呼吸内科,江西萍乡337000

出　　处：《中国当代医药》2022年第18期40-43,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202140497)。

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者呼出气一氧化氮(FeNO)与白细胞介素-17(IL-17)、肺功能的相关性。方法选取2020年9月至2021年3月萍乡市人民医院收治的80例AECOPD患者为病例组,并选取同期的60例健康者作为对照组,测定AECOPD患者加重期、稳定期两个时期以及对照组的FeNO、IL-17与肺功能水平,分析FeNO与IL-17及肺功能[第1秒用力呼气容积(FEV_(1))、FEV_(1)与用力肺活量(FVC)的比值(FEV_(1)/FVC)]的相关性。结果COPD患者两个时期的FeNO、IL-17水平高于对照组,差异有统计学意义(P<0.05);COPD患者两个时期的肺功能水平(FEV_(1)、FEV_(1)/FVC)低于对照组,差异有统计学意义(P<0.05)。AECOPD患者的FeNO与IL-17、FEV_(1)、FEV_(1)/FVC无相关性(P>0.05);COPD患者的FeNO与IL-17呈正相关(r=0.236,P<0.05),与肺功能指标FEV_(1)、FEV_(1)/FVC呈负相关(r=-0.178、-0.316,P<0.05)。结论FeNO与IL-17、FEV_(1)、FEV_(1)/FVC具有一定的相关性,可作为评价COPD的有效指标。Objective To investigate the correlation between fractional exhaled nitric oxide(FeNO)and interleukin-17(IL-17)and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 80 patients with AECOPD admitted to Pingxiang People′s Hospital from September 2020 to March 2021 were selected as the case group,and 60 healthy patients in the same period were selected as the control group.The levels of FeNO,IL-17 and lung function were measured in patients with AECOPD during the exacerbation period and the stable period,as well as in the control group.The correlation between FeNO,IL-17 and lung function(the first second forced expiratory volume[FEV_(1)],the ratio of FEV_(1)to forced vital capacity[FVC][FEV_(1)/FVC])was analyzed.Results The levels of FeNO and IL-17 in the COPD patients in the two periods were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of lung function(FEV_(1),FEV_(1)/FVC)in the COPD patients in the two periods were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no correlation between FeNO and IL-17,FEV_(1),FEV_(1)/FVC in AECOPD patients(P>0.05).There was a positive correlation between FeNO and IL-17(r=0.236,P<0.05),and a negative correlation with lung function(FEV_(1),FEV_(1)/FVC)(r=-0.178,-0.316,P<0.05).Conclusion FeNO has a certain correlation with IL-17 and FEV_(1),FEV_(1)/FVC,and it can be used as an effective index for the evaluation of COPD.

关 键 词：慢性阻塞性肺疾病 急性加重期 呼出气一氧化氮 白细胞介素-17 肺功能 相关性 

分 类 号：R563.9[医药卫生—呼吸系统]