羟考酮复合舒芬太尼对老年胃肠道恶性肿瘤患者开腹术后镇痛效果分析  

Analgesic Effe ct of Oxycodone Combined with Sufentanil on Elderly Patients with Gastrointestinal Tumor after Open Surgery

作　　者：王立红 傅润乔 Wang Lihong;Fu Runqiao(Department of Anesthesiology,Beijing Chui Yang Liu Hospital,Chui Yang Liu Hospital Affiliated to Tsinghua University,Beijing 100022,China)

机构地区：[1]清华大学附属垂杨柳医院[北京市垂杨柳医院]麻醉科,北京100022

出　　处：《巴楚医学》2022年第2期67-71,共5页Bachu Medical Journal

基　　金：北京市朝阳区科技计划项目(No:CYSF181102)。

摘　　要：目的:探讨羟考酮复合舒芬太尼对老年胃肠道肿瘤患者开腹手术后的镇痛效果。方法:80例胃肠道肿瘤行开腹手术患者,按数字表法随机分为S、OS组两组,每组40例。术后自控静脉镇痛,S组为舒芬太尼2μg/kg+托烷司琼10 mg;OS组为羟考酮0.5 mg/kg+舒芬太尼1μg/kg+托烷司琼10 mg。观察两组患者术后镇静、镇痛效果及血流动力学指标。结果:OS组48 h内静态、动态VAS评分均明显低于S组(均P<0.05)。OS组48 h内自控按压次数、不良反应总发生率均明显少于S组(均P<0.05),患者满意率明显高于S组(P<0.05)。OS组的收缩压、心率血压乘积在气管导管拔除后5 min、术后3 h、6 h、12 h及24 h均明显低于S组(P<0.05)。结论:羟考酮联合舒芬太尼能有效抑制老年胃肠道恶性肿瘤患者开腹根治术后疼痛,减少不良反应,降低应激反应。Objective: To investigate the analgesic effect of oxycodone combined with sufentanil on elderly patients with gastrointestinal tumors undergoing open surgery. Methods: A total of 80 patients with gastrointestinal tumor underwent open radical resection were randomly divided into Group S and Group OS, with 40 cases in each group. Postoperative patient-controlled intravenous analgesia was performed. Group S were treated with sufentanil of 2 μg/kg and tropisetron of 10 mg. Group OS were treated with oxycodone of 0.5 mg/kg, sufentanil of 1 μg/kg and tropisetron of 10 mg. Postoperative sedation, analgesia and hemodynamic indexes were compared between two groups.Results: Both static VAS and dynamic VAS scores in Group OS were significantly lower than those in Group S within 48 h(all P<0.05). Frequency of patient-controlled analgesia and total incidence of adverse reactions in Group OS were significantly lower than those in Group S(all P<0.05), while total satisfaction rate of patients was significantly higher than that in Group S(P < 0.05). Systolic pressure and heart rate-blood pressure product were significantly lower in Group OS than those in Group S at 5 min after extubation, 3 h, 6 h, 12 h and 24 h after surgery(all P<0.05).Conclusion: Oxycodone combined with sufentanil can effectively inhibit pain and reduce adverse reactions and stress response in elderly patients with gastrointestinal tumor after radical gastrectomy.

关 键 词：羟考酮 舒芬太尼 胃肠道肿瘤 开腹手术 镇痛 

分 类 号：R614[医药卫生—麻醉学]