重组人表皮生长因子对云南高海拔地区敏感性肌肤的修复效果  

Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province

作　　者：周箐竹 龚桌 赵娴 刘博言 黄文莉 赫佳 刘旒 浦仆飞 ZHOU Qingzhu;GONG Zhuo;ZHAO Xian;LIU Boyan;HUANG Wenli;HE Jia;LIU Liu;PU Pufei(Dept.of Plastic Surgery of Kunming First People’s Hospital,Kunming Yunnan 650000,China)

机构地区：[1]昆明市第一人民医院整形美容科,云南昆明650000

出　　处：《昆明医科大学学报》2022年第6期41-45,共5页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81860343);云南省昆明市西山区科技计划项目(西科字23号)。

摘　　要：目的观察重组人表皮生长因子(Research and Application of Recombinant Human Epidermal Growth actor,EGF)对云南高海拔地区敏感性肌肤的修复效果。方法回顾性分析2021年03月至2021年09月收集采样100例20岁至60岁云南籍皮肤敏感的女性受试者伴有发红、瘙痒、红血丝、色斑、毛孔粗大等症状。分为对照组(25例)和实验1组(25例),实验2组(25例),实验3组(25例),4组均使用德玛莎1代电子注射仪进行常规14 mg/mL的非交联透明质酸钠2 mL真皮层全脸注射,每30 d注射1次,连续注射5次,实验1组每次注射添加10000 UEGF溶液,实验2组每次注射添加5000 UEGF溶液,实验3组添加2500单位EGF溶液。注射前使用VISIA皮肤检测仪进行数据分析并分别记录4组注射前,1次注射后、2次注射后、3次注射后、4次注射后、5次注射后的受试者皮肤敏感自评数据、医生客观评分数据及VISIA红区特征计数数据。收集整理后进行统计分析。并对照前后皮肤质地,肤色,毛孔改善情况。结果数据分析结果显示:(1)实验组,敏感肌肤修复效果明显高于对照组(P<0.05);(2)实验组受试者皮肤敏感自评及医生客观评分明显高于对照组(P<0.05);(3)实验组1组修复效果及速率明显高于实验2组与实验3组(P<0.05);(4)实验组对皮肤的色斑、皱纹、毛孔均有改善。结论重组人表皮生长因子(EGF)可以有效修复云南高海拔地区敏感性肌肤,为云南皮肤治疗提供新的临床思路。Objective To observe the repairing effect of recombinant human epidermal growth factor(EGF)on sensitive skin in high altitude area of Yunnan province.Methods This study retrospectively analyzed 100 cases of sensitive skin female patients aged 20 to 60 years old from Yunnan in our institution from March 2021 to September 2021,accompanied by redness,itching,red blood streaks,stains,enlarged pores and other symptoms.The subjects were divided into control group(n=25),experiment group 1(n=25),experiment group 2(n=25),experiment group 3(n=25).All the 4 groups were injected 14mg/ml non-crosslinked sodium hyaluronate 2ml into the dermis of the whole face with DermaShine model 1 generation electronic injection,once every 30 days for 5 consecutive times,experimental group 1 was injected with 10000 units of EGF solution each time,experimental group 2 was injected with 5000 units of EGF solution each time,experimental group 3 was injected with 2500 solution units of EGF each time.VISIA skin analysis apparatus was used for data analysis before and after injection,and patients'skin sensitivity self-assessment data,doctor's objective score data and VISIA red zone feature count data were recorded before injection,after 1 injection,2 injections,3 injections,4 injections and 5 injections respectively.All data were collected for statistical analysis.The improvement of skin texture,color and pore was compared before and after injection.Results Data analysis results showed that,1.The repairing effect of sensitive skin in the experimental group was significantly higher than that in the control group(P<0.05).2.The self-assessment of skin sensitivity and the objective score of doctors in the experimental group was significantly higher than that in the control group(P<0.05).3.The repair effect rate of experimental group 1 was significantly higher than that in experimental group 2 and experimental group 3(P<0.05).4.The experimental group improved the skin spots,wrinkles and pores.Conclusion EGF can effectively repair sensitive skin in hig

关 键 词：重组人表皮生长因子 非交联透明质酸钠 高海拔 敏感肌肤 修复 

分 类 号：R75[医药卫生—皮肤病学与性病学]