胆绿素治疗作用的研究进展  

Advances in Research Progress on the Therapeutic Function of Biliverdin

作　　者：白文娅 杨渊 霍思颖 杨鑫[1] 邵建林[1] BAI Wenya;YANG Yuan;HUO Siying;YANG Xin;SHAO Jianlin(Dept.of Anesthesiology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院麻醉科,云南昆明650032

出　　处：《昆明医科大学学报》2022年第6期147-153,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81960250);云南省教育厅科研基金资助项目(2022J0192);云岭产业技术领军人才项目(YLXL20170054)。

摘　　要：胆绿素、胆红素是血红素代谢的产物。有研究发现,胆绿素依靠胆绿素-胆红素氧化还原系统,不断地消耗氧自由基,激活胆绿素还原酶,从而发挥抗氧化、抗炎、抑制免疫反应、稳定血管内皮细胞、调控细胞凋亡等作用。将从胆绿素、胆红素的结构与代谢、胆绿素的作用及机制等方面作一综述。Biliverdin and bilirubin are the products of heme metabolism.Many studies have found that biliverdin can continuously consume oxygen free radicals as well as activate biliverdin reductase,relying on the biliverdin-bilirubin redox recycling system.Biliverdin may play a crucial of antioxidant,anti-inflammatory,suppressing immune response,stabilizing vascular endothelial cells,regulating cell apoptosis and so on.In this review,we discussed the structure and metabolism of biliverdin/bilirubin,and mechanism of biliverdin therapeutic function in different diseases.

关 键 词：胆绿素 胆绿素-胆红素氧化还原系统 氧化应激 免疫炎症 细胞凋亡 

分 类 号：R614.2[医药卫生—麻醉学]