基于药物基因组学对《运动员常用治疗药物使用指南(2020版)》的解读  

Interpretation of Guidelines for the Use of Commonly Used Therapeutic Drugs in Athletes(2020 Edition)Based on Pharmacogenomics

作　　者：吴竞鲜 何霞 边原[1,2] 杜姗 刘心霞[1,2] 童荣生 王俊丽[3] 问媛媛 袁梦莹[4] WU Jingxian;HE Xia;BIAN Yuan;DU Shan;LIU Xinxia;TONG Rongsheng;WANG Junli;WEN Yuanyuan;YUAN Mengying(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Personalized Drug Therapy Key Laboratory of Sichuan Province,Department of Pharmacy,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital / Affiliated Hospital of University of Electronic Science and Technology of China,Chengdu 610072,China;Xi'an Tianlong Science and Technology Co.,Ltd,Xi'an 710018,China;School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]电子科技大学医学院,成都610054 [2]四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部·个体化药物治疗四川省重点实验室,成都610072 [3]西安天隆科技有限公司,西安710018 [4]成都中医药大学药学院,成都611137

出　　处：《医药导报》2022年第6期813-820,共8页Herald of Medicine

基　　金：国家重点研发计划(2020YFC2005500);四川省科技厅重点研发计划(2019YFS0514);四川省科技厅重点研究计划(2022YFS0272);四川省人民医院院基金资助项目(2020LY06)。

摘　　要：第二十四届冬奥会于2022年2月在北京举行。我国针对运动员常用药物制订《运动员常用治疗药物使用指南(2020版)》,并公布《兴奋剂目录(2022)》,以便于更好管理运动员用药。随着精准医学的发展,药物基因组学已成为指导临床个体化用药、评估药物疗效和不良反应发生风险的重要工具,药物基因组学结合遗传信息指导临床合理用药是精准医学的新兴应用之一。该文结合药物基因组学,对运动员常用的抗病毒药(利巴韦林),局部麻醉药(利多卡因和罗哌卡因),解热、镇痛、抗炎、抗痛风药(阿司匹林、布洛芬、美洛昔康),心血管系统药(氯沙坦、缬沙坦、卡托普利、氨氯地平、硝苯地平和阿托伐他汀钙片),消化系统药(奥美拉唑、泮托拉唑)等14个药物对应的基因位点进行综述,并归纳这14个药物的药物基因组临床应用证据级别,以期为运动员个体化用药提供参考依据。The 24th Winter Olympic Games was held in China in February,2022.At present,China has formulated the Guidelines for the Use of Commonly Used Drugs for Athletes(2020 edition),and published the Doping Catalogue(2022),to facilitate a better management on the drug use for athletes.With the development of precision medicine,pharmacogenomics has become an essential tool to guide personalized drug use and evaluate drug efficacy and the risk of severe adverse reactions.Pharmacogenomics combined with genetic information to guide clinical rational drug use is one of the emerging applications of precision medicine.In this paper,the gene loci of 14 commonly used drugs for athletes,such as antiviral drugs(ribavirin),local anesthetics(lidocaine and ropivacaine),nonsteroidal anti-inflammatory drugs(aspirin,ibuprofen,and meloxicam),cardiovascular drugs(losartan,valsartan,captopril,amlodipine,nifedipine,and atorvastatin calcium tablet),digestive system drugs(omeprazole,pantoprazole)were reviewed.The levels of the evidence for clinical application of pharmacogenomics in these 14 drugs are summarized,to provide a relatively comprehensive reference basis for personalized drug use for athletes.

关 键 词：药物基因组学 基因多态性 运动员常用治疗药物 运动员 个体化用药 

分 类 号：R954[医药卫生—药学]