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作 者:刘琪文 杨德智[1] 杨秀颖 吕扬[1] 杜冠华[2] LIU Qiwen;YANG Dezhi;YANG Xiuying;LYU Yang;DU Guanhua(Beijing Key Laboratory of Polymorphs Drugs Research;Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
机构地区:[1]北京协和医学院中国医学科学院药物研究所晶型药物研究北京市重点实验室,北京100050 [2]北京协和医学院中国医学科学院药物研究所药物靶点研究与新药筛选北京市重点实验室,北京100050
出 处:《医药导报》2022年第6期848-852,共5页Herald of Medicine
基 金:国家新药创制重大专项-重大新药创制(2018ZX09711001-001-015,2018ZX09711001-003-022);国家重点研发计划(2016YFC1000900);中国医学科学院医学与健康创新工程(2016-I2M-3-007);抗新冠病毒的创新药物与机理研究(2020-I2M-1-003)。
摘 要:糖尿病肾病(DN)是糖尿病的一种重要的微血管并发症,其发病率在全球范围内呈上升趋势,是慢性肾脏病和终末期肾病的主要病因。目前临床上治疗DN的药物主要是降压降血糖药物,而针对于DN的发病机制的药物正处于临床试验阶段,但一些药疗效欠佳,不良反应严重。研究表明,从中药大黄分离提纯得到的天然蒽醌类化合物大黄酸,对DN有潜在的治疗作用,其作用方式是多靶点多途径的综合结果。大黄酸对机体的抗炎、抗氧化性应激,并抑制转化生长因子活性等作用机制,是治疗DN的新策略。该文综述近年国内外对大黄酸在DN方面的作用及机制最新研究进展,分析大黄酸对DN的治疗前景,为大黄酸的进一步开发提供理论科学依据。Diabetic nephropathy(DN)is one of the critical microvascular complications of diabetes mellitus,and the incidence is still increasing worldwide.DN is a significant cause of chronic kidney disease and end-stage renal disease.At present,drugs in the clinical treatments for DN are mainly antihypertensive and hypoglycemic drugs.There are several drugs targeting the pathogenesis of DN in the clinical trial stage,but many of them have poor efficacy or adverse effects.Studies have shown that Rhein,a natural anthraquinone compound isolated and purified from Chinese medicine rhubarb,has a potential therapeutic effect on DN,and its mode of action is a complex result of multiple targets and pathways.The mechanism of action of Rhein on DN includes anti-inflammatory and antioxidant stress,and inhibits transforming growth factor activity(TGF-β_(1)).These combined effects are the new strategy for the treatment of DN.This article reviews the latest research progresses on the effects and mechanisms of Rhein in DN,analyzes the therapeutic prospects of Rhein on DN,and provides theoretical and scientific basis for the further development of Rhein.
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