Antifouling and antimicrobial cobaltocenium-containing metallopolymer double-network hydrogels  

作　　者：Hui Li Peng Yang JiHyeon Hwang Parasmani Pageni Alan W.Decho Chuanbing Tang 

机构地区：[1]Department of Chemistry and Biochemistry,University of South Carolina,Columbia,SC,USA [2]School of Chemistry and Chemical Engineering,University of Jinan,Jinan,Shandong Province,China [3]Department of Environmental Health Sciences,Arnold School of Public Health,University of South Carolina,Columbia,SC,USA

出　　处：《Biomaterials Translational》2022年第2期162-171,共10页生物材料转化电子杂志（英文）

基　　金：The study was supported by the National Institutes of Health(No.R01AI120987).

摘　　要：Compared with single-network hydrogels,double-network hydrogels offer higher mechanical strength and toughness.Integrating useful functions into double-network hydrogels can expand the portfolios of the hydrogels.We report the preparation of double-network metallopolymer hydrogels with remarkable hydration,antifouling,and antimicrobial properties.These cationic hydrogels are composed of a first network of cationic cobaltocenium polyelectrolytes and a second network of polyacrylamide,all prepared via radical polymerization.Antibiotics were further installed into the hydrogels via ion-complexation with metal cations.These hydrogels exhibited significantly enhanced hydration,compared with polyacrylamide-based hydrogels,while featuring robust mechanical strength.Cationic metallopolymer hydrogels exhibited strong antifouling against oppositely charged proteins.These antibiotic-loaded hydrogels demonstrated a synergistic effect on the inhibition of bacterial growth and antifouling of bacteria,as a result of the unique ion complexation of cobaltocenium cations.

关 键 词：ANTIMICROBIAL cobaltocenium double network hydrogel METALLOPOLYMER 

分 类 号：O63[理学—高分子化学]