支气管哮喘气道重塑机制的研究进展  

Research progress in the mechanism of airway remodeling in bronchial asthma

作　　者：刘健[1] Jian Liu(The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学第二附属医院,天津300250

出　　处：《中国现代医学杂志》2022年第12期51-54,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81804026)。

摘　　要：气道重塑是哮喘难以根治的主要原因,预防气道重塑具有重要的临床意义。普遍认为气道重塑是由于气道慢性炎症导致气道反复损伤和异常修复引起的。与此同时,也有研究显示单纯治疗气道炎症并不能直接缓解气道重塑,但气道收缩引发的机械力也能导致气道结构的改变。笔者将近年来关于气道重塑发生机制的研究进行综述,从而为哮喘的治疗提供新思路。Airway remodeling represents the main cause for that asthma is difficult to be cured,and prevention of airway remodeling is of important clinical significance.It is traditionally believed that airway remodeling results from the repetitive airway injury and abnormal repair caused by the chronic airway inflammation.Meanwhile,some studies revealed that treating airway inflammation alone cannot directly alleviate the airway remodeling and that the mechanical force via airway contraction can also lead to changes in the airway structure.This paper reviews the advances in the mechanism of airway remodeling in recent years,so as to provide novel insights for the treatment of asthma.

关 键 词：支气管哮喘 气道炎症 气道重塑 气道收缩 机械力 

分 类 号：R562.25[医药卫生—呼吸系统]