青海果洛和西宁地区健康人群及HAPC患者的血液COR、ALD以及相关炎症因子水平  

Study on the levels of blood COR,ALD and related inflammatory factors in healthy people and patients with high altitude polycythemia(HAPC)in Golok and Xining of Qinghai province

作　　者：王洋 杜慧 张经善 刘永年[1] WANG Yang;DU Hui;ZHANG Jingshan;LIU Yongnian(Medical College of Qinghai University,Xining 810001,China;Graduate School of Qinghai University,Xining 810016,China;Qinghai Provincial People's Hospital,Xining 810007,China;People's Hospital of Golok Prefecture,Guoluo 814099,China)

机构地区：[1]青海大学医学院,青海西宁810001 [2]青海大学研究生院,青海西宁810016 [3]青海省人民医院,青海西宁810007 [4]果洛州人民医院,青海果洛814099

出　　处：《中国高原医学与生物学杂志》2022年第3期180-183,共4页Journal of Chinese High Altitude Medicine & Biology

基　　金：青海省应用基础项目(2015-SF-124,2019-ZJ-7006)。

摘　　要：目的 明确青海果洛和西宁地区健康人群及HAPC患者的血液COR、ALD及相关炎症因子水平。方法 选择84名西宁(海拔2200m)和99名果洛地区(海拔3800m)的移居与世居居住者,分成2 200m世居组(10人)、2 200m移居组(74人)、3 800m世居组(77人)、3 800m移居组(22人);从西宁移居人群中选择29名HAPC患者组成病例组,74名健康者组成对照组。晨起抽取空腹静脉血,采用化学发光法检测COR、ALD水平;应用酶联免疫法检测血浆IL-3、IL-6、hs-CRP水平。采用非参数检验进行统计学分析。结果 3800m移居组COR水平显著小于2 200m移居组(P<0.05),3800m移居组IL-3水平显著小于2200m移居组、3800m世居组(P<0.05),ALD、IL-6、hs-CRP均无统计学差异(P>0.05);病例组COR、IL-6、IL-3、hs-CRP水平高于对照组,差异有统计学意义(P<0.05)。结论 果洛健康人群COR、IL-3水平低于西宁人群;HAPC人群COR、IL-3、IL-6、hs-CRP水平高于西宁人群。青海果洛和西宁地区健康人群及HAPC患者血液COR及IL-3、IL-6、hs-CRP水平存在差异。Objective To determine the levels of blood COR,ALD and related inflammatory factors in healthy people and patients with high altitude polycythemia(HAPC)in Golok and Xining of Qinghai province.Methods There were 84 immigrants and permanent residents of Xining(altitude of 2200 m)and 99 immigrants and permanent residents of Golok prefecture(altitude of 3800 m)selected in the study.They were divided into four groups, including permanent resident group of 2 200 m(10 people),immigrant group of 2 200 m(74 people),permanent resident group of 3 800 m(77 people)and immigrant group of 3 800 m(22 people);a total of 29 HAPC patients from Xining immigrants were selected as the case group and 74 healthy Xining immigrants as the control group.Fasting venous blood was taken in the morning, and the levels of COR and ALD were detected by chemiluminescence;plasma levels of IL-3,IL-6 and hs-CRP were detected by ELISA. Non-parametric test was used for statistical analysis.Results The level of COR in the immigrant group of 3 800 m was significantly lower than that in the immigrant group of 2 200 m(P<0.05).The level of IL-3 in the immigrant group of 3 800 m was significantly lower than that in the immigrant group of 2 200 m and permanent resident group of 3 800 m(P<0.05).There was no significant difference in ALD,IL-6 and hs-CRP(P>0.05);The levels of COR,IL-6,IL-3 and hs-CRP in the case group were higher than those in the control group.The difference was statistically significant(P<0.05).Conclusion The levels of COR and IL-3 in Golok healthy people were lower than those in Xining;The levels of COR,IL-3,IL-6 and hs-CRP in HAPC group were higher than those in Xining group.There were differences in the levels of blood COR、IL-3、IL-6 and hs-CRP between healthy people and HAPC patients in Golok and Xining of Qinghai.

关 键 词：青海 健康者 高原红细胞增多症 皮质醇 醛固酮 炎症因子 

分 类 号：R339.54[医药卫生—人体生理学] R364.5[医药卫生—基础医学]