基于生物学信息分析染色体分离1样基因在预测胃癌预后中的价值  

Values of chromosome segregation 1-like gene in predicting the prognosis of gastric cancer based on biological information analysis

作　　者：史虎祥 刘珺 苏占海[1] 刘燕[1] SHI Huxiang;LIU Jun;SU Zhanhai;LIU Yan(Medical College of Qinghai University,Xining 810001,China;Medical College of Xi'an Jiaotong University,Xi'an 710049,China)

机构地区：[1]青海大学医学院,青海西宁810001 [2]西安交通大学医学院,陕西西安710049

出　　处：《中国高原医学与生物学杂志》2022年第2期127-133,共7页Journal of Chinese High Altitude Medicine & Biology

基　　金：国家自然科学基金项目(81960451);青海省科技厅自然基金项目(2019-ZJ-7055);青海大学医学院科研团队项目(2018-kyt-2)。

摘　　要：目的 基于生物学信息分析染色体分离1样基因(CSE1L)在预测胃癌预后中的价值。方法 使用GEPLA数据平台分析CSE1L在肿瘤组织与癌旁正常组织中的表达情况,以及CSE1L的表达与胃癌患者病理分期之间的关系;利用在线数据平台Kaplan-Meier plotter分析CSE1L表达水平与胃癌患者总生存时间(OS)和首次进展生存期(FP)之间的关系;绘制CSE1L蛋白互作网络图,并进行功能富集分析,分析其作用机制。结果 GEPLA数据平台基因检测结果显示,CSE1L基因在胃癌组织中的表达水平显著升高(P<0.05),CSE1L的表达与胃癌患者的病理分期没有显著差异(P>0.05);Kaplan-Meier plotter在线数据平台分析结果显示,CSE1L表达高的胃癌患者OS、FP较低表达患者更短(P<0.05);功能富集分析显示,CSE1L及互作蛋白参与核转运,影响肿瘤的进展。结论 CSE1L可能是胃癌新的预后和潜在治疗标志物,其可通过影响核转运促进肿瘤的进展。Objective To investigate the values of chromosome segregation 1-like(CSE1 L)gene in predicting the prognosis of gastric cancer based on biological information analysis.Methods GEPLA data platform was used to analyze the expression of CSE1 L in tumor tissues and adjacent normal tissues as well as the relationship between CSE1 L expression and pathological stage of patients with gastric cancer;Kaplan Meier plotter, an online data platform was used to analyze the relationship between CSE1 L expression level and overall survival time(OS)and first progression survival time(FP)in patients with gastric cancer;the interaction network diagram of CSE1 L protein was drawn and functional enrichment analysis was performed to analyze its mechanism.Results The data from GEPLA database showed that CSE1 L was highly expressed in gastric cancer tissues(P<0.05),and there was no significant difference between CSE1 L expression and pathological stage of patients with gastric cancer(P>0.05);the analysis of Kaplan-Meier plotter online platform showed that gastric cancer patients with high CSE1 L expression had shorter OS and FP than those with low CSE1 L expression(P<0.05);functional enrichment analysis showed that CSE1 L and interacting proteins were involved in nuclear transport, affecting the progression of tumor.Conclusion CSE1 L may be a new prognostic and potential therapeutic marker for gastric cancer, which may promote tumor progression by influencing the nuclear transport.

关 键 词：生物学 信息 分析 预测 胃癌 价值 

分 类 号：R3[医药卫生—基础医学]