骨密度测定联合β-crosslaps和PINP检测在预测绝经后骨质疏松症中的应用研究  

The research on the clinical application of double X-ray absorptionmetry combined with β-crosslaps and PINP detection in predicting postmenopausal osteoporosis

作　　者：蔡浩颖[1] 李林昌[1] CAI Hao-ying;LI Lin-chang(Department of Radiology,the Affiliated Hospital of Qinghai University,Xining,Qinghai,810001,China)

机构地区：[1]青海大学附属医院放射科,青海西宁810001

出　　处：《中国冶金工业医学杂志》2022年第3期249-250,共2页Chinese Medical Journal of Metallurgical industry

基　　金：青海省卫健委医药卫生项目课题(2019-wjzdx-51)。

摘　　要：目的探讨双能X线骨密度测定(DXA)联合总骨Ⅰ型前胶原氨基末端肽(PINP)和β-胶原特殊序列(β-crosslaps)检测在预测绝经后骨质疏松症(POP)中的应用效果。方法收集2019年10月至2020年10月于我院就诊的绝经后女性100例作为对象,根据DXA测定结果将其分为骨质疏松组与非骨质疏松组,每组各50例。测定两组骨密度水平,比较两组的β-crosslaps和PINP值。结果骨质疏松组髋关节、股骨颈及腰椎的骨密度水平均明显低于非骨质疏松组,组间比较差异均有统计学意义(t=14.94、13.99、14.13,均P<0.05);骨质疏松组的β-crosslaps、PINP水平均高于非骨质疏松组,组间比较差异均有统计学意义(t=6.86、16.19,均P<0.05)。结论绝经后女性骨密度及骨代谢标志物水平与骨质疏松的发生关系密切,DXA联合β-crosslaps、PINP检测可作为预测POP的指标。Objective To investigate the clinical application and research of double X-ray absorptionmetry(DXA)combined with total bone typeⅠprocollagen amino terminal peptide(PINP)andβ-collagen specific sequence(β-crosslaps)in predicting postmenopausal osteoporosis(POP).Methods A total of 100 postmenopausal women examined in our hospital from Oct.2019 to Oct.2020 were selected and divided into osteoporosis group and non-osteoporosis group according to the results of DXA,50 patients in each group.The level of bone mineral density were measured,PINP andβ-crosslaps value of the two groups were compared.Results The bone mineral density of the hip joint,femoral neck and lumbar spine in the osteoporosis group were significantly lower than those in the non-osteoporosis group,and the differences between the groups were statistically significant(t=14.94,13.99,14.13,all P<0.05);The levels ofβ-crosslaps and PINP in the osteoporosis group were higher than those in the nonosteoporosis group,and the differences between the groups were statistically significant(t=6.86,16.19,both P<0.05).Conclusion The level of bone mineral density and bone metabolism markers of postmenopausal women are closely related to the occurrence of osteoporosis.DXA combined withβ-crosslaps and PINP testing can be used as ideal indicators to predict POP.

关 键 词：绝经后骨质疏松症 双能X线骨密度 β-crosslaps PINP 

分 类 号：R589.5[医药卫生—内分泌]