小分子共价DNA的组装及生物医学应用  

Self-Assembly of Small Molecule Modified DNA and Their Application in Biomedicine

作　　者：马佳慧 袁伟 刘思敏 赵智勇 Jiahui Ma;Wei Yuan;Simin Liu;Zhiyong Zhao(The State Key Laboratory of Refractories and Metallurgy,School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,China;Hubei Key Laboratory of Pollutant Analysis&Reuse Technology,Hubei Normal University,Huangshi 435002,China)

机构地区：[1]武汉科技大学,化学与化工学院,耐火材料与冶金国家重点实验室,武汉430081 [2]湖北师范大学,污染物分析与资源化技术湖北省重点实验室,黄石435002

出　　处：《化学进展》2022年第4期837-845,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21604066,21871216);湖北省教育厅科学技术研究项目(No.B2016012)资助。

摘　　要：DNA,由于其精确的碱基互补配对、良好的生物相容性、稳定的物理化学性质,不仅可用于组装各种形状和尺寸的纳米结构,而且可以设计动态的纳米器件。为了进一步拓展DNA的应用,可通过化学修饰引入功能分子或基团,从而实现二者功能的集成。目前,DNA与高分子、树状分子、多肽和蛋白等共价有机杂化体的合成、组装及在药物运输和控释等领域的应用已研究得比较成熟,而结构和功能多样的小分子与DNA共价杂化体,由于疏水小分子体积小,其组装受到限制,近年来科研者通过结构衍生或增多芳香环等研究其组装行为及应用。本文主要综述了疏水小分子共价连接DNA后的组装行为及其在生物医药领域的潜在应用,并对这类杂化体纳米材料的研究前景进行了展望。Due to the addressability,programmability and excellent biocompatibility,DNA has been applied not merely in constructing static elegant nanostructures with different shapes and sizes,but also in designing dynamic nanodevices.Moreover,to further expand the application of DNA,functional groups or molecules can be conjugated with DNA through chemical modification.DNA could combine with hydrophobic organic molecules to be a new amphiphilic building block and then self-assemble into nanomaterials.So far,DNA has been covalent with polymers,dendrimers,peptides or proteins,and the assembly behavior and potential application of these hybrids have been widely investigated.Of particular note,recent state-of-the-art research has turned our attention to the amphiphilic DNA organic hybrids,including small molecule modified DNA(lipid-DNA,fluorescent molecule-DNA,etc.).This review focuses mainly on the development of their self-assembly behavior and their potential application in biomedicine.The potential challenges regarding the amphiphilic DNA organic hybrids are also briefly discussed,aiming to advance their practical applications in nanoscience and biomedicine.

关 键 词：DNA-小分子杂化体 共价连接 组装调控 生物医学应用 

分 类 号：Q522[生物学—生物化学] Q523