手性药物及其中间体光学纯度的测定方法与应用  

Determination methods and applications of optical purity of chiral drugs and their intermediates

作　　者：李陈宗 朱园园 古双喜 LI Chenzong;ZHU Yuanyuan;GU Shuangxi(Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering&Pharmacy,Wuhan Institute of Technology,Wuhan 430205,China;School of Chemistry and Environmental Engineering,Wuhan Institute of Technology,Wuhan 430205,China;Hubei Key Laboratory of Novel Reactor and Green Chemical Technology,Wuhan Institute of Technology,Wuhan 430205,China)

机构地区：[1]武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室,武汉430205 [2]武汉工程大学化学与环境工程学院,武汉430205 [3]武汉工程大学,新型反应器与绿色化学工艺湖北省重点实验室,武汉430205

出　　处：《分析试验室》2022年第5期588-599,共12页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金面上项目(22074114,21877087,20602164);湖北省自然科学基金(2020CFB623);绿色化工过程教育部重点实验室开放基金(GCP20200201);新型反应器与绿色化学工艺湖北省重点实验室开放基金(K202004)资助。

摘　　要：手性是自然界的基本属性,在动植物生命活动、医药、农药及化学工业中发挥着重要作用。已上市药物中有一半以上是手性药物,正在开发的临床药物有约2/3药物是具有手性的。因此,手性化合物的光学纯度测定尤为重要。目前手性化合物光学纯度的测定方法以色谱法和光谱法为主,同时辅以其他方法。本文结合手性荧光识别与光学纯度分析中的研究成果,对色谱法、光谱法和其他光学纯度测定方法及其应用进行了综述,以期为手性药物及其中间体的光学纯度测定提供信息与参考。Chirality is the basic characteristic of nature.Chirality plays an important role in the life activities of animals and plants,pharmaceuticals,pesticides as well as chemical industries.More than half of the approved drugs are chiral drugs,and about two-thirds of the drugs in development are also chiral.Therefore,the optical purity determination of chiral compounds is particularly important.At present,the determination methods for optical purity are mainly based on chromatography and spectroscopy,and also supplemented by other methods.In this review,the author combined the research results in chiral fluorescence recognition and optical purity analysis to review these methods and corresponding applications,which aims to afford useful information and reference for optical purity determination of chiral drugs and their intermediates in future.

关 键 词：手性药物 对映体纯度 光学纯度测定 对映体过量值 光谱法 色谱法 

分 类 号：O656.3[理学—分析化学]