不同严重程度的甲型H1N1流行性感冒患者的临床特征分析  

Clinical characteristics of influenza A(H1N1)patients with varying degrees of severity

作　　者：靳妍玉 韩李周[1] Jin Yanyu;Han Lizhou(Department of Pulmonary and Critical Care Medicine,Jiaozuo People’s Hospital,Jiaozuo 454002,China)

机构地区：[1]河南省焦作市人民医院呼吸与危重症医学科,焦作454002

出　　处：《中国实用医刊》2022年第6期35-38,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析不同严重程度的甲型H1N1流行性感冒(以下简称流感)患者的临床特征。方法抽取2019年1月至2月焦作市人民医院呼吸与危重症医学科病房收治的50例甲型H1N1流感患者的临床资料,根据病情严重程度将患者分为危重组(24例)和普通组(26例),回顾性分析两组患者的临床特征。结果危重组患者年龄大于普通组(P<0.05)。危重组患者合并基础疾病的比例高于普通组(P<0.05)。危重组患者中性粒细胞、C-反应蛋白、乳酸脱氢酶、D-二聚体水平高于普通组(P<0.05),危重组患者淋巴细胞、血清白蛋白水平低于普通组(P<0.05)。两组患者胸部CT常表现为磨玻璃影,危重组可有实变渗出影。危重组给予气管插管机械通气11例,死亡9例,普通组无死亡病例。结论合并内科疾病的老年患者感染甲型H1N1病毒后病情较危重,淋巴细胞计数减少、低蛋白血症、乳酸脱氢酶升高、D-二聚体升高是危重患者的临床特征。Objective To analyze the clinical characteristics of influenza A(H1N1)patients with varying degrees of severity.Methods The clinical data of 50 patients with influenza A(H1N1)in the Pulmonary and Critical Care Medicine Ward of Jiaozuo People’s Hospital from January to February 2019 were selected.According to the severity of illness,the patients were divided into critical group(24 cases)and ordinary group(26 cases),and the clinical characteristics of the two groups were retrospectively analyzed.Results The age of the critical group was older than that of the ordinary group(P<0.05).The proportion of patients with underlying diseases in the critical group was higher than that in the ordinary group(P<0.05).The levels of neutrophils,C-reactive protein,lactate dehydrogenase and D-dimer in the critical group were higher than those in the ordinary group(P<0.05);while the levels of lymphocytes and serum albumin in the critical group were lower than those in the ordinary group(P<0.05).The chest CT of the two groups often showed ground-glass opacity,and there were consolidation and exudation shadows in the critical group.In the critical group,11 patients were given tracheal intubation and mechanical ventilation,and 9 cases died.There was no death in the ordinary group.Conclusions Elderly patients with internal diseases are prone to aggravation after infection with influenza A(H1N1)virus.Decreased lymphocyte count,hypoalbuminemia,elevated lactate dehydrogenase,and elevated D-dimer are the clinical characteristics of critically ill patients.

关 键 词：流行性感冒 淋巴细胞 白蛋白 乳酸脱氢酶 

分 类 号：R511.7[医药卫生—内科学]