替格瑞洛联合阿托伐他汀钙在冠心病患者PCI术后的应用价值  

Effect of ticagrelor combined with atorvastatin calcium on patients with coronary heart disease after PCI

作　　者：王永民[1] 张平[2] 元晓敏 Wang Yongmin;Zhang Ping;Yuan Xiaomin(Department of Pharmacy,the Third People’s Hospital of Anyang,Anyang 455000,China;Department of Cardiovascular Medicine,the Third People’s Hospital of Anyang,Anyang 455000,China)

机构地区：[1]河南省安阳市第三人民医院药剂科,安阳455000 [2]河南省安阳市第三人民医院心血管内科,安阳455000

出　　处：《中国实用医刊》2022年第6期100-103,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析替格瑞洛联合阿托伐他汀钙在冠心病患者经皮冠状动脉介入术(PCI)术后的应用价值。方法抽取2017年3月至2020年5月安阳市第三人民医院收治的冠心病患者102例,按随机数字表法分为联合组与单一组,每组51例。两组均行PCI术治疗,单一组术后予以阿托伐他汀钙,联合组在单一组基础上予以替格瑞洛。比较两组疗效、心功能、纤溶功能、冠状动脉造影情况、血脂水平及心脏不良事件发生率。结果联合组总有效率(96.08%,49/51)高于单一组(90.39%,41/51),P<0.05。治疗后,联合组心排出量、左心室射血分数高于单一组(P<0.05);纤维蛋白原低于单一组、组织型纤溶酶原激活物高于单一组(P<0.05)。术后6个月,联合组冠状动脉狭窄程度低于单一组,最小管腔直径大于单一组(P<0.05)。治疗后,联合组三酰甘油、低密度脂蛋白胆固醇水平低于单一组(P<0.05)。联合组心脏不良事件发生率(8.16%,4/49)低于单一组(24.00%,12/50),P<0.05。结论冠心病PCI术后应用替格瑞洛联合阿托伐他汀钙效果显著,可调节血脂水平,改善纤溶功能和心功能,预防发生心脏不良事件。Objective To analyze the effect of ticagrelor combined with atorvastatin calcium on patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 102 patients with coronary heart disease treated in the Third People’s Hospital of Anyang from March 2017 to May 2020 were selected,and they were divided into combined group and single group by random number table method,with 51 cases in each group.Both groups were treated by PCI;the single group was treated with atorvastatin calcium,and the combined group was treated with ticagrelor based on the treatment of the single group.Efficacy,cardiac function,fibrinolytic function,coronary angiography,blood lipid levels,and incidence of adverse cardiac events were compared between the two groups.Results The total effective rate of combined group(96.08%,49/51)was higher than that of single group(90.39%,41/51),P<0.05.Compared with single group,the cardiac output and left ventricular ejection fraction in the combined group were higher after treatment(P<0.05).Compared with single group,fibrinogen was lower and tissue plasminogen activator was higher in the combined group after treatment(P<0.05).Compared with single group,the degree of coronary stenosis in the combined group was lower,and the minimum lumen diameter was thicker 6 months after operation(P<0.05).Compared with single group,the expressions of triglyceride and low density lipoprotein cholesterol in the combined group were lower after treatment(P<0.05).The incidence of adverse cardiac events in combined group(8.16%,4/49)was lower than that in single group(24.00%,12/50),P<0.05.Conclusions Ticagrelor combined with atorvastatin calcium after PCI has a significant effect on coronary heart disease,which can regulate blood lipid level,improve fibrinolytic function and cardiac function,and prevent adverse cardiac events.

关 键 词：冠心病 经皮冠状动脉介入术 替格瑞洛 阿托伐他汀钙 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]