瘢痕疙瘩中的成纤维细胞特性研究进展  

Research advances on the characteristics of fibroblast in keloid

作　　者：王蕴璋 苏晨[2] 付思祺[3] 刘立强 Yunzhang Wang;Chen Su;Siqi Fu;Liqiang Liu(Department Nine of Plastic Surgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences,Beijing 100144,China;Emergency Department,the Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518033,China;Department of Dermatology,the Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中国医学科学院整形外科医院整形九科,北京100144 [2]中山大学附属第八医院急诊科,深圳518033 [3]中南大学湘雅二医院皮肤科,长沙410011

出　　处：《中华烧伤与创面修复杂志》2022年第6期590-594,共5页Chinese Journal of Burns And Wounds

摘　　要：近20年来,细胞生物学技术的发展推动了瘢痕疙瘩的相关研究。瘢痕疙瘩成纤维细胞(KFb)是瘢痕疙瘩中的主要效应细胞,与瘢痕疙瘩的发生发展密切相关。KFb在生物学特性、基因表达等方面与正常成纤维细胞有明显差异。该文从多个角度对KFb的特性进行了综述,详细描述了其生物学特性如显微结构、代谢特点、增殖性质等情况,并介绍了KFb的异质性与基因组学等方面的主要特征。对KFb研究的不断深入将有助于阐明瘢痕疙瘩的发病机制并为瘢痕疙瘩的防治提供宝贵策略。In re-cent 20 years,the development of cell biology technology has promoted the research of keloid.Keloid fibroblasts(KFbs)are the main effector cells in keloid,which are closely related to the occurrence and development of keloid.It is significantly different in terms of biological characteristics and gene expression between KFbs and normal fibroblasts.This articles reviews the characteristics of KFbs from multiple perspectives,describing its biological character-istics in details including microstructures,metabolic character-istics,and proliferation properties,and introducing the main characteristics of heterogeneity and genomics of KFbs.The further research on KFbs will help to elucidate the pathogenesis of keloids and provide valuable strategies for the prevention and treatment of keloids.

关 键 词：瘢痕疙瘩 成纤维细胞 基因 生物学特性 信号通路 

分 类 号：R622[医药卫生—整形外科]