环状RNA在糖尿病及其慢性并发症中的机制研究  

Circular RNA in Diabetes and its Complications

作　　者：张懿恋 张诗雨 胡吉[1] 张弘弘[1] ZHANG Yilian;ZHANG Shiyu;HU Ji;ZHANG Honghong(Department of Endocrinology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China)

机构地区：[1]苏州大学附属第二医院内分泌科,江苏苏州215004

出　　处：《中国医学科学院学报》2022年第3期521-528,共8页Acta Academiae Medicinae Sinicae

摘　　要：环状RNA(circRNA)是一类特殊的非编码RNA,与线性RNA不同,circRNA是前信使RNA(pre-mRNA)通过反向剪接形成的封闭环状结构,表达高度稳定并广泛分布在真核生物中。circRNA主要通过充当微RNA(miRNA)海绵或与RNA结合蛋白结合发挥多种功能。circRNA可作为多种疾病的生物标志物。最新研究表明,circRNA在糖尿病和相关慢性并发症的发生发展中也起着重要作用。本综述旨在总结目前circRNA在糖尿病及其相关并发症发生发展中的作用及其机制的研究进展。Circular RNA(circRNA)is a special group of non-coding RNA.Unlike linear RNA,circRNA is a closed circular structure formed by reverse splicing of pre-mRNA,with highly stable expression and wide distribution in eukaryotes.CircRNA has multiple functions by acting as microRNA sponges or binding with RNA-binding proteins.They can be used as biomarkers for many diseases.The latest research shows that circRNA plays a role in the pathogenesis of diabetes mellitus and the related chronic complications.In this review,we summarized the current progress and underlying mechanisms of circRNA in diabetes mellitus and the related complications.

关 键 词：糖尿病 糖尿病慢性并发症 环状RNA 

分 类 号：R4[医药卫生—临床医学]