老年性上睑下垂发生机制研究进展  

Research progress of the mechanism of senile ptosis

作　　者：周荣(综述) 高伟成(审校)[1] ZHOU Rong;GAO Weicheng(Department of Plastic and Cosmetic Surgery,The Affiliated Friendship Plastic Surgical Hospital,Nanjing Medical University,Nanjing 210029,China.)

机构地区：[1]南京医科大学友谊整形外科医院整形外科,江苏省南京市210029

出　　处：《组织工程与重建外科》2022年第3期281-283,共3页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：老年性上睑下垂临床较为常见,不仅影响外观,严重者导致视力受限。多数研究认为,老年性上睑下垂是由于上睑提肌腱膜损伤,自睑板上缘断裂等引起。近年来的研究表明,Müller肌的纤维化和脂肪化、上睑提肌纤维数量减少和脂肪化、氧化应激等,也会引起或加重老年性上睑下垂。本文对老年性上睑下垂可能的病因及致病机制进行综述,为临床诊治提供理论依据。Senile ptosis is one of the common diseases among the elderly, which not only affects the appearance, but also limits the eyesight, resulting in dysfunction. Currently, concrete pathological mechanism of senile ptosis is not clear. Major scholars suggest that levator aponeurosis injury and the rupture of the upper edge of the tarsal plate may cause senile ptosis.Recently, many studies show that fibrosis and fatty infiltration of Müller’s muscle, decrease and fatty infiltration of levator fibers and oxidative stress may lead to and aggravate senile ptosis. The possible causes and pathogenesis of senile ptosis were reviewed in this paper, providing theoretical evidence for clinical therapies.

关 键 词：老年性上睑下垂 上睑提肌腱膜 Müller肌 氧化应激 

分 类 号：R622[医药卫生—整形外科]