新生儿中枢神经系统脲原体感染的特点及其防治研究进展  

Progress on the characteristics, prevention and treatment of neonatal central nervous system ureaplasma infection

作　　者：张丽花 郑美玉 张玥 吕小明 武辉[1] Zhang Lihua;Zheng Meiyu;Zhang Yue;Lyu Xiaoming;Wu Hui(Department of Neonatology,Bethune First Hospital of Jilin University,Changchun 130012,China)

机构地区：[1]吉林大学白求恩第一医院新生儿科,长春130012

出　　处：《中国小儿急救医学》2022年第5期383-388,共6页Chinese Pediatric Emergency Medicine

摘　　要：脲原体为机会性病原体,人群携带率高,母体脲原体感染与早产等不良妊娠结局有关。新生儿脲原体感染可致中枢神经系统炎症,最终可导致新生儿不良神经系统预后。虽然新生儿侵袭性中枢神经系统感染发病率低,但由于脲原体感染后体内对其存在免疫逃逸、感染后临床表现不典型、常规检测手段不敏感等原因,使新生儿中枢神经系统脲原体感染常不能及时诊断和正规治疗,贻误治疗时机,导致严重并发症。本文通过对脲原体感染所致中枢神经系统炎症相关发病机制、临床表现、并发症、诊断及相关案例的成功治疗经验等内容进行阐述,为临床上新生儿脲原体神经系统感染提供早期诊断及合理治疗的依据,进而减少脲原体感染所致不良神经系统结局的发生。Ureaplasma is an opportunistic pathogen with a high population carrying rate.Maternal ureaplasma infection is related to adverse pregnancy outcomes such as premature birth etc.Ureaplasma infection in neonates can cause central nervous system inflammation and eventually lead to poor nervous system prognosis.Although the incidence of invasive central nervous system infection in newborns is low,due to the presence of immune escape in the body,atypical clinical manifestations after ureaplasma infection,and insensitivity to routine detection methods,the central ureaplasma infection in newborns is often unable to diagnose and treat properly in time,so it can easily lead to delayed treatment,which can lead to serious complications.This review aimed to explain the pathogenesis,clinical manifestations and complications of central nervous system inflammation caused by ureaplasma infection,and share diagnosis methods,as well as successful treatment experience in related cases,so as to provide the basis for early diagnosis and reasonable treatment,thereby reducing the occurrence of adverse neurological outcomes caused by ureaplasma infection.

关 键 词：新生儿 脲原体 脑膜炎 中枢神经系统 

分 类 号：R722.1[医药卫生—儿科]