高同型半胱氨酸血症与结缔组织病合并心血管疾病  

Hyperhomocysteinemia and Connective Tissue Disease Combined with Cardiovascular Disease

作　　者：晏唯 张艺文 聂琼 吴镜 YAN Wei;ZHANG Yiwen;NIE Qiong;WU Jing(Southwest Jiaotong University Medical School,Chengdu 610031,Sichuan,China;Department of Geriatrics,The Affiliated Hospital of Southwest Jiaotong University,The Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan,China)

机构地区：[1]西南交通大学医学院,四川成都610031 [2]西南交通大学附属医院成都市第三人民医院老年科,四川成都610031

出　　处：《心血管病学进展》2022年第6期522-525,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81300243);四川省科技厅面上项目(2019YJ0634);四川省医学科研青年创新课题(Q14013);四川省卫健委普及应用项目(16PJ042)。

摘　　要：结缔组织病是一组全身性炎症性的自身免疫性疾病,可累及全身多个脏器,其中以心血管系统最为严重。同型半胱氨酸是一种含巯基的氨基酸,是甲硫氨酸循环的中间产物,与心血管疾病的发生、发展密切相关,被认为是心血管疾病独立危险因素。近年来相关研究表明,结缔组织病患者存在高同型半胱氨酸血症,且与心血管疾病发生风险相关,高同型半胱氨酸血症可能在结缔组织病并发心血管疾病中发挥重要作用。Connective tissue disease is a group of systemic inflammatory autoimmune diseases that can affect multiple organs throughout the body,of which the cardiovascular system is the most serious.Homocysteine is a sulfhydryl-containing amino acid and an intermediate product of the methionine cycle.It is closely related to the occurrence and development of cardiovascular disease and is considered an independent risk factor for cardiovascular disease.In recent years,relevant studies have shown that patients with connective tissue diseases have hyperhomocysteinemia and are related to the risk of cardiovascular disease.Hyperhomocysteinemia may play an important role in connective tissue diseases complicated by cardiovascular disease.

关 键 词：同型半胱氨酸 高同型半胱氨酸血症 结缔组织病 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]