重组人脑利钠肽联合尼可地尔治疗急性心肌梗死合并心力衰竭的疗效  

Efficacy of recombinant human brain natriuretic peptide combined with nicorandil in the treatment of acute myocardial infarction with heart failure and its effect on patients’cardiac function

作　　者：董荣 王志华 陈龙锦 DONG Rong;WANG Zhihua;CHEN Longjin(Department of Cardiovascular Medicine,Yancheng NO1 People’s Hospital,Yancheng 224000,China)

机构地区：[1]盐城市第一人民医院心血管内科,盐城224000

出　　处：《西北药学杂志》2022年第4期112-116,共5页Northwest Pharmaceutical Journal

基　　金：江苏省科技厅科研项目(编号:BK20200265)。

摘　　要：目的探讨重组人脑利钠肽(rhBNP)联合尼可地尔治疗急性心肌梗死(AMI)合并心力衰竭患者的疗效,并分析其心功能的变化情况。方法选择112例AMI合并心力衰竭患者作为研究对象,按照随机数字表法分为2组,各56例。2组患者均在入院后予以常规治疗,对照组在此基础上加用尼可地尔治疗,观察组在对照组治疗的基础上加用rhBNP治疗。比较分析2组患者的临床疗效、治疗前后心功能变化、N端前脑钠肽(NT-ProBNP)、高敏肌钙蛋白T(hs-cTnT)、脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))和血管紧张素Ⅱ(AngⅡ)水平,并随访不良事件发生情况。结果观察组治疗总有效率较对照组更高(P<0.05)。治疗后观察组左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)、NT-ProBNP、hs-cTnT、Lp-PLA_(2)和AngⅡ水平均较对照组更低,左室射血分数(LVEF)水平较对照组更高(P<0.05)。随访半年观察组不良事件发生率较对照组更低(P<0.05)。结论rhBNP联合尼可地尔有助于改善AMI合并心力衰竭患者的心室功能,加快机体循环系统恢复,具有较高的安全性。Objective To investigate the efficacy of recombinant human brain natriuretic peptide(rhBNP)combined with nicorandil in the treatment of patients with acute myocardial infarction(AMI)and heart failure,and to analyze the changes in cardiac function.Methods A total of 112 patients with AMI and heart failure were selected as the research subjects,and were grouped according to the number random table method,each with 56 cases.Patients in both groups were treated with routine treatment after admission.The control group were treated with nicorandil,and the observation group were treated with rhBNP on the basis of routine treatment and the control group.The clinical efficacy,changes in cardiac function before and after treatment,N-terminal probrain natriuretic peptide(NT-ProBNP),high-sensitivity troponin T(hs-cTnT),lipoprotein-related phospholipase A_(2)(Lp-PLA_(2)),angiotensinⅡreceptor antagonist(AngⅡ)and follow-up adverse events were compared and analyzed.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the observation group had lower levels of left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),NT-ProBNP,hs-cTnT,Lp-PLA_(2)and AngⅡ,and higher left ventricular ejection fraction(LVEF)levels than the control group(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group during the half-year follow-up(P<0.05).Conclusion rhBNP combined with nicorandil treatment can help improve the ventricular function of AMI complicated with heart failure,speed up the recovery of the body’s circulatory system,and has high safety.

关 键 词：重组人脑利钠肽(rhBNP) 尼可地尔 急性心肌梗死 心力衰竭 心功能 安全性 

分 类 号：R972[医药卫生—药品]