特发性膜性肾病无创生物学标志物的研究进展  

Research Progress of Noninvasive Biomarkers in Idiopathic Membranous Nephropathy

作　　者：覃勋[1] QIN Xun(Department of Nephrology,Hechi People's Hospital,Hechi,Guangxi Zhuang Autonomous Region,547000 China)

机构地区：[1]河池市人民医院肾内科,广西河池547000

出　　处：《系统医学》2022年第10期190-193,共4页Systems Medicine

基　　金：河池市科学研究与技术开发计划项目(河科B1824-9)。

摘　　要：随着不断加深对特发性膜性肾病(idiopathic membranous nephropathy,IMN)机制的研究,血清、尿液中的生物标志物如血清M型磷脂酶A2受体、1型血小板反应蛋白7A域、人类白细胞DR抗原、溶酶体膜蛋白-2、非编码RNA等与IMN发生、发展密切相关,对IMN的鉴别诊断具有深远的意义。故该文就目前IMN患者无创生物学标志物的研究现状作一综述,为临床上更好地监测IMN活动、评估疗效和预测进展提供参考依据。With the deepening of the research on the mechanism of idiopathic membranous nephropathy(IMN),biomarkers in serum and urine such as serum M-type phospholipase A2 receptor,type 1 thrombospondin 7A domain,human leukocyte DR antigen,lysosomal membrane protein-2,non-coding RNA,etc.are closely related to the occurrence and development of IMN,and have far-reaching significance for the differential diagnosis of IMN.Therefore,this article reviews the current research status of non-invasive biomarkers in patients with IMN,and provides a reference for better clinical monitoring of IMN activity,evaluation of efficacy and prediction of progress.

关 键 词：特发性膜性肾病 生物学标志物 PLA2R THSD7A HLA-DR 

分 类 号：R322.61[医药卫生—人体解剖和组织胚胎学]