血清IL-1、D-D水平与下肢动脉硬化闭塞症患者腔内介入治疗后再狭窄的关系  

Relationship of serum IL-1 and D-D levels with restenosis after endovascular intervention in patients with lower extremity arteriosclerosis obliterans

作　　者：贾萌 唐启耀 尹君 熊臣 Jia Meng;Tang Qiyao;Yin Jun;Xiong Chen(Department of Interventional Radiology,Xinyang Central Hospital,Xinyang 463600,China)

机构地区：[1]河南省信阳市中心医院介入放射科,信阳463600

出　　处：《中国实用医刊》2022年第7期43-46,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清白细胞介素-1(IL-1)、D-二聚体(D-D)水平与下肢动脉硬化闭塞症(LEASO)患者腔内介入治疗后再狭窄发生的关系。方法抽取信阳市中心医院2018年2月至2019年9月接受腔内介入治疗的116例LEASO患者为研究对象,治疗后随访2年,观察患者随访期间再狭窄发生情况并将患者分为再狭窄组与无再狭窄组,调查并记录患者基线资料,于入院时检测血清IL-1、D-D水平,分析血清IL-1、D-D水平与LEASO患者腔内介入治疗后再狭窄的关系。结果治疗后随访2年,116例患者中,47例发生再狭窄,占40.52%;再狭窄组患者入院时血清IL-1水平为(0.75±0.12)ng/L、D-D水平为(0.63±0.10)mg/L,高于无再狭窄组患者的(1.26±0.21)ng/L、(1.05±0.16)mg/L(P<0.05);经Logistic回归分析结果显示,血清IL-1、D-D过表达与LEASO患者腔内介入治疗后再狭窄发生有关(P<0.05)。结论血清IL-1、D-D过表达与LEASO患者腔内介入治疗后再狭窄发生有关。Objective To investigate the relationship of serum IL-1 and D-D levels with restenosis after endovascular intervention in patients with lower extremity arteriosclerosis obliterans(LEASO).Methods A total of 116 patients with LEASO who underwent endovascular interventional therapy in Xinyang Central Hospital from February 2018 to September 2019 were selected as the research objects.They were followed up for 2 years after treatment.The occurrence of restenosis during follow-up was observed,and the 116 patients with LEASO were divided into restenosis group and no restenosis group.The baseline data of patients were investigated and recorded.The serum IL-1 and D-D levels were detected at admission,and the relationship of serum IL-1 and D-D levels with restenosis after intracavitary interventional therapy in patients with LEASO was analyzed.Results During 2-year follow-up after treatment,47 cases of the 116 patients had restenosis,accounting for 40.52%;the levels of serum IL-1 and D-D in the restenosis group were(0.75±0.12)ng/L and(0.63±0.10)mg/L,respectively,which were higher than the(1.26±0.21)ng/L and(1.05±0.16)mg/L in the non restenosis group(P<0.05).Results of Logistic regression analysis showed that the overexpression of serum IL-1 and D-D was related to the occurrence of restenosis after intracavitary interventional therapy in patients with LEASO(P<0.05).Conclusions The overexpression of serum IL-1 and D-D is related to the occurrence of restenosis after intracavitary interventional therapy in patients with LEASO.

关 键 词：下肢 动脉硬化闭塞症 腔内介入治疗 再狭窄 白细胞介素-1 D-二聚体 

分 类 号：R543.5[医药卫生—心血管疾病]