Is early patent ductus arteriosus ligation helpful in premature neonates? A 10-year retrospective study  

作　　者：Anip Garg Naveen Athiraman Elizabeth Jenkins David Crossland Prakash Kannan Loganathan 

机构地区：[1]Neonatal Unit,Royal Victoria Infirmary,Newcastle,UK [2]Paediatric Cardiology,Freeman Hospital,Newcastle,UK [3]Neonatal Unit,James Cook University Hospital,Marton Road,Middlesbrough TS43BW,UK

出　　处：《World Journal of Pediatrics》2022年第5期350-357,共8页世界儿科杂志（英文版）

摘　　要：Background To compare short and long outcomes between early(≤28 days)(EL)and late ligation(LL)groups.To explore factors predicting early extubation(≤7 days)after patent ductus arteriosus(PDA)ligation.Methods We conducted a single center,retrospective cohort study of preterm infants<32 weeks who underwent surgical ligation over a 10-year period(2009-2019).Results A total of 133 infants underwent PDA ligation,in the study period.Both groups had similar short-term outcome such as bronchopulmonary dysplasia(BPD)or death(96%vs.98%,P=0.64)and long-term clinical outcomes including Bayley's assessment at 2 years corrected age.Fewer infants in the EL group developed severe BPD(63%vs.81%,P=0.02).Age at ligation had adjusted odds ratio of 1.04 with over lapping confidence interval(95%CI 1.0-1.1,P=0.02)for severe BPD/death.There was no difference in day of extubation between the EL and LL group(8 days vs.7 days,P=0.85).Left atrium/aortic root ratio of ≥1.75 would give sensitivity of 41% and 80% specificity for early extubation(area under the curve of 0.61).There was marginal reduction of hospital stay in the EL group[113(105-121)days vs.115(107-123)days;log rank P=0.026].Conclusion EL can be delivered safely with a clinically important lower incidenee of severe BPD and shorter duration of hospital stay compared to LL.

关 键 词：Bronchopulmonary dysplasia EXTUBATION Patent ductus arteriosus ligation 

分 类 号：R722[医药卫生—儿科] R543[医药卫生—临床医学]