眼部化妆品中有机汞含量与微生物检出的相关性  

Correlation Between Organic Mercury Content and Microbial Detection in Eye Cosmetics

作　　者：牟建平 滕宝霞 贺晓文 朱玲 肖静 曾小梅 MOU Jianping;TENG Baoxia;HE Xiaowen;ZHU Ling;XIAO Jing;ZENG Xiaomei(Gansu Institute for Drug Control,Lanzhou 730060,Gansu,China)

机构地区：[1]甘肃省药品检验研究院,甘肃兰州730060

出　　处：《香料香精化妆品》2022年第3期61-65,共5页Flavour Fragrance Cosmetics

基　　金：甘肃省药品监督管理局药品科研项目(编号2020GSM PA004,2019GSMPA025)。

摘　　要：考察眼部化妆品中有机汞(Hg)含量与微生物检出的相关性。参照《化妆品安全技术规范》(2015年版)微生物检验方法和《中国药典》(2020年版)通则1105微生物计数法,对眼部化妆品(分别含Hg70、14、2.8、0 mg/kg)进行微生物挑战性试验,包括微生物计数(菌落总数、霉菌和酵母菌总数)和控制菌(金黄色葡萄球菌、铜绿假单胞菌和耐热大肠菌群)的生长试验。结果显示眼部化妆品中有机汞(硫柳汞)的含量对样品中微生物的检出存在影响,当Hg含量为2.8、14、70 mg/kg时,抑菌作用强,应建立适宜的方法消除供试品的抑菌作用后进行微生物指标的检查,才能真实反映产品的卫生质量。所以进行以有机汞为防腐剂的眼部化妆品微生物指标检查时,应进行方法学适用性试验,可选择大肠埃希菌作为阳性质控菌。The correlation between the content of organic mercury and microbial detection in eye cosmetics was investigated.Microbial counts(total number of colonies,total number of molds and yeasts)and control bacteria(Staphylococcus aureus,Pseudomonas aeruginosa and heat-resistant coliforms)were performed on eye cosmetics(containing Hg 70,14,2.8 and 0 mg/kg,respectively)with reference to the microbiological test method of 2015 Technical Specification for Cosmetic Safety and the microbial count method of 2020 Chinese Pharmacopoeia,General Rule 1105.The content of organic mercury(thimerosal)in eye cosmetics has an effect on the detection of microorganisms in samples,and when the Hg content is 2.8 to 70 mg/kg,a suitable method should be established to eliminate the inhibition effect before conducting the microbiological index examination to truly reflect the hygienic quality of the product.Escherichia coli should be selected as positive quality control bacteria when conducting microbiological index examination of eye cosmetics.

关 键 词：眼部化妆品 有机汞 微生物 硫柳汞 方法验证 

分 类 号：TQ658[化学工程—精细化工]