盐酸坦索罗辛缓释胶囊联合体外冲击波碎石治疗泌尿系结石的临床效果  

Clinical effect of tamsulosin hydrochloride sustained release capsule combined with extracorporeal shock wave lithotripsy in the treatment of urinary calculi

作　　者：康文玉 张治国 KANG Wenyu;ZHANG Zhiguo(Yan'an City Hospital of TCM,Yan'an 716000;Gem Flower Xi'an Changqing Staff Hospital,Xi'an 710201,China)

机构地区：[1]延安市中医医院,陕西延安716000 [2]西安宝石花长庆医院,陕西西安710201

出　　处：《临床医学研究与实践》2022年第19期73-76,81,共5页Clinical Research and Practice

摘　　要：目的探讨盐酸坦索罗辛缓释胶囊联合体外冲击波碎石(ESWL)治疗泌尿系结石的临床效果。方法选取2019年6月至2021年4月我院收治的150例泌尿系结石患者作为研究对象,按照奇偶分类法将其分为对照组(75例,ESWL治疗)和观察组(75例,盐酸坦索罗辛缓释胶囊+ESWL治疗)。比较两组的临床治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。观察组的腰痛减轻时间、肉眼血尿消失时间及结石排尽时间均短于对照组(P<0.05)。治疗后3、7 d,两组的视觉模拟评分法(VAS)和排尿感觉量表(USS)评分均降低,且观察组低于对照组(P<0.05)。治疗后,两组的血肌酐(Scr)及血尿素氮(BUN)水平及24 h尿蛋白定量均降低,且观察组低于对照组(P<0.05)。治疗后,两组的24 h尿液中钙、草酸、尿酸含量均降低,且观察组低于对照组(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。治疗后,两组的匹兹堡睡眠质量指数(PSQI)评分均降低,健康调查简表(SF-36)评分均升高,且观察组优于对照组(P<0.05)。治疗后3、6、9个月,观察组的复发率略低于对照组,但差异无统计学意义(P>0.05)。结论盐酸坦索罗辛缓释胶囊联合ESWL治疗泌尿系结石的临床效果显著,可改善患者的临床症状及肾功能,降低尿中钙、草酸、尿酸含量,改善患者的睡眠质量及生活质量,值得临床推广和应用。Objective To investigate the clinical effect of tamsulosin hydrochloride sustained release capsule combined with extracorporeal shock wave lithotripsy(ESWL)in the treatment of urinary calculi.Methods A total of 150 patients with urinary calculi admitted in our hospital from June 2019 to April 2021 were selected as the research objects,and the patients were divided into control group(75 cases,ESWL treatment)and observation group(75 cases,tamsulosin hydrochloride sustained release capsule+ESWL treatment)according to the odd-even classification method.The clinical treatment effect of the two groups was compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The relief time of low back pain,disappearance time of gross hematuria and stone elimination time in the observation group were shorter than those in the control group(P<0.05).At 3 and 7 d after treatment,the scores of visual analogue scale(VAS)and urinary sensation scale(USS)in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN)and 24 h urinary protein quantitation in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the contents of calcium,oxalic acid and uric acid in the 24 h urine of the two groups decreased,and those in the observation group were lower than the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).After treatment,the Pittsburgh sleep quality index(PSQI)score in the two groups decreased,and the MOS item short from health survey(SF-36)score in the two groups increased,and those in the observation group were better than the control group(P<0.05).At 3,6 and 9 months after treatment,the recurrence rate in the observation group was slightly lower than that in the control group,but the difference was not statis

关 键 词：盐酸坦索罗辛缓释胶囊 体外冲击波碎石 泌尿系结石 肾功能 24 h尿生化学指标 

分 类 号：R692.4[医药卫生—泌尿科学]