清肺止咳汤联合西药治疗小儿支原体肺炎的临床效果及安全性  

Clinical effect and safety of Qingfei Zhike decoction combined with western medicine in the treatment of mycoplasma pneumonia in children

作　　者：方万红 安婷婷 FANG Wanhong;AN Tingting(the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000;Xi'an Daxing Hospital,Xi'an 710016,China)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712000 [2]西安大兴医院,陕西西安710016

出　　处：《临床医学研究与实践》2022年第19期126-129,共4页Clinical Research and Practice

摘　　要：目的分析清肺止咳汤联合西药治疗小儿支原体肺炎的临床效果及安全性。方法选取2019年1月至2021年1月本院收治的84例支原体肺炎患儿为研究对象,根据红绿双色球法将其分为对照组(n=42,西药治疗)与观察组(n=42,清肺止咳汤联合西药治疗)。比较两组的中医证候积分、炎性因子水平[白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、免疫功能指标[白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原8阳性(CD8^(+))]、通气功能指标[用力肺活量(FVC)、潮气量(VT)、达峰时间比(TPTEF/TE)]、不良反应发生情况及治疗效果。结果治疗14 d后,两组患儿咳嗽、发热、喘促积分低于治疗前,且观察组低于对照组(P<0.05)。治疗14 d后,两组患儿的IL-8、IL-10、CRP以及TNF-α水平低于治疗前,且观察组低于对照组(P<0.05)。治疗14 d后,两组患儿的CD3^(+)、CD4^(+)高于治疗前,CD8^(+)低于治疗前,且观察组优于对照组(P<0.05)。治疗14 d后,两组患儿的FVC、VT以及TPTEF/TE高于治疗前,且观察组高于对照组(P<0.05)。观察组的不良发应总发生率低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。结论清肺止咳汤联合西药治疗小儿支原体肺炎的效果显著,有利于改善中医证候以及炎症反应,增强患儿的免疫功能,减少不良反应,值得临床进一步推广应用。Objective To analyze the clinical effect and safety of Qingfei Zhike decoction combined with western medicine in the treatment of mycoplasma pneumonia in children. Methods Eighty-four children with mycoplasma pneumonia admitted in our hospital from January 2019 to January 2021 were selected as the research objects. According to the red and green double color ball method, the children were divided into control group(n =42, western medicine treatment) and observation group(n =42, Qingfei Zhike decoction combined with western medicine treatment). The traditional Chinese medicine syndromes scores, inflammatory factors levels [interleukin-8(IL-8), interleukin-10(IL-10),C-reactive protein(CRP), and tumor necrosis factor-α(TNF-α)], immune function indexes [cluster of differentiation 3positive(CD3^(+)), cluster of differentiation 4 positive(CD4^(+)), cluster of differentiation 8 positive(CD8^(+))], ventilation function indexes [forced vital capacity(FVC), tidal volume(VT), ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE)], adverse reactions and therapeutic effects were compared between the two groups. Results After 14 d of treatment, the scores of cough, fever and wheezing in the two groups were lower than those before treatment, and those in the observation group were lower than the control group(P<0.05). After 14 d of treatment, the levels of IL-8, IL-10, CRP and TNF-α in the two groups were lower than those before treatment, and those in the observation group were lower than the control group(P <0.05). After 14 d of treatment, CD3^(+)and CD4^(+)in the two groups were higher than those before treatment, CD8^(+)was lower than that before treatment, and those in the observation group were better than the control group(P<0.05). After 14 d of treatment, FVC, VT and TPTEF/TE in the two groups were higher than those before treatment, and those in the observation group were higher than the control group(P<0.05). The total incidence of adverse reactions in the observation group was lower than t

关 键 词：支原体肺炎 小儿 清肺止咳汤 安全性 

分 类 号：R272[医药卫生—中医儿科学]