麦冬汤合牛膝饮加味治疗2型糖尿病合并高血压的临床效果  

Clinical effect of modified Maidong decoction and Niuxi drink in the treatment of type 2 diabetes mellitus complicated with hypertension

作　　者：王小姝 赵丽[1] WANG Xiaoshu;ZHAO Li(Traditional Chinese Medicine Hospital of Baoji,Baoji 721001,China)

机构地区：[1]宝鸡市中医医院,陕西宝鸡721001

出　　处：《临床医学研究与实践》2022年第19期130-134,共5页Clinical Research and Practice

摘　　要：目的探究麦冬汤合牛膝饮加味治疗2型糖尿病(T2DM)合并高血压(HP)的临床效果。方法将2019年1月至2020年12月我院收治的78例T2DM合并HP患者随机分为对照组和观察组,各39例。对照组采用常规西药治疗,观察组在对照组基础上给予麦冬汤合牛膝饮加味治疗。比较两组的临床疗效、血压控制效果、血糖代谢指标、血清学指标、血脂指标、药物不良反应及生活质量。结果观察组的治疗总有效率为97.44%,明显高于对照组的76.92%(P<0.05)。治疗后,两组的24 h动态收缩压(SBP)、舒张压(DBP)均减小,昼夜SBP、DBP差值均增大,且观察组优于对照组(P<0.05)。治疗后,两组的日内平均血糖波动幅度(MAGE)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及空腹胰岛素(FINS)水平均明显降低,且观察组低于对照组(P<0.05)。治疗后,两组的半胱氨酸蛋白酶抑制剂C(CysC)、转化生长因子β1(TGF-β1)、脂蛋白相关磷脂酶A2(Lp-PLA2)、白细胞介素-6(IL-6)水平均明显降低,且观察组低于对照组(P<0.05)。治疗后,两组的高密度脂蛋白胆固醇(HDL-C)水平均升高,总胆固醇(TC)、三酰甘油(TG)水平均降低,且观察组优于对照组(P<0.05)。两组的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,两组的中医高血压量表(PRO)及2型糖尿病患者生活质量量表(DMQLS)评分均明显降低,且观察组低于对照组(P<0.05)。结论麦冬汤合牛膝饮加味治疗T2DM合并HP患者的效果显著,可有效控制血压,改善血糖、血脂及血清学指标水平,提高患者的生活质量,值得推广。Objective To explore the clinical effect of modified Maidong decoction and Niuxi drink in the treatment of type 2 diabetes mellitus(T2DM) complicated with hypertension(HP). Methods A total of 78 T2DM patients with HP admitted in our hospital from January 2019 to December 2020 were randomly divided into control group and observation group, with 39 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with modified Maidong decoction and Niuxi drink on the basis of the control group. The clinical efficacy,blood pressure control effects, blood glucose metabolism indexes, serological indexes, blood lipid indexes, adverse drug reactions and quality of life were compared between the two groups. Results The total effective rate of treatment in the observation group was 97.44%, which was significantly higher than 76.92% in the control group(P<0.05). After treatment,the 24 h dynamic systolic blood pressure(SBP) and diastolic blood pressure(DBP) of the two groups decreased, the differences between day and night SBP and DBP increased, and those in the observation group were better than the control group(P <0.05). After treatment, the mean amplitude of glycemic excursions(MAGE), fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c) and fasting insulin(FINS) levels in the two groups significantly decreased, and those in the observation group were lower than the control group(P <0.05). After treatment, the levels of cystatin C(CysC),transforming growth factor-β1(TGF-β1), lipoprotein-associated phospholipase A2(Lp-PLA2) and interleukin-6(IL-6) in the two groups significantly decreased, and those in the observation group were lower than the control group(P<0.05). After treatment, the level of high density lipoprotein cholesterol(HDL-C) in the two groups increased, and the levels of total cholesterol(TC) and triglyceride(TG) decreased, and those in the observation group were better than the control group(P<0.05). There was no significant difference in th

关 键 词：2型糖尿病 高血压 麦冬汤合牛膝饮 血清学指标 生活质量 

分 类 号：R259[医药卫生—中西医结合]