定喘汤配合常规西药治疗咳嗽变异性哮喘疗效观察及对血清ICAM-1、Eotaxin水平的影响  

Observation on Curative Effect of Dingchuan Tang Combined with Routine Western Medicine for Cough Variant Asthma and Its Effect on ICAM-1 and Eotaxin Levels in Serum

作　　者：李慧娇[1] 王一萍[1] 何薇[1] 尤志新 LI Huijiao;WANG Yiping;HE Wei;YOU Zhixin

机构地区：[1]绍兴市中医院呼吸科,浙江绍兴312000

出　　处：《新中医》2022年第10期61-65,共5页New Chinese Medicine

摘　　要：目的:观察定喘汤联合常规西药治疗咳嗽变异性哮喘(CVA)的临床疗效及其对血清外周血细胞间黏附分子-1(ICAM-1)、嗜酸细胞活化趋化因子(Eotaxin)水平的影响。方法:将76例CVA患者按随机数字表法分为治疗组与对照组各38例。对照组给予常规西药治疗,治疗组在对照组的基础上给予定喘汤治疗。2组均以8周为1个疗程。治疗1个疗程后评估2组临床疗效、肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))及第1秒呼气容积占用力呼气量百分比(FEV_(1)/FVC)],以及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、白细胞介素-13(IL-13)水平,ICAM-1、Eotaxin水平。结果:治疗后,治疗组总有效率为92.11%,对照组73.68%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组FVC、FEV_(1)、FEV_(1)/FVC水平比较,差异无统计学意义(P>0.05);治疗后,2组上述肺功能指标均较治疗前明显升高(P<0.05),且治疗组各项指标均明显高于对照组(P<0.05)。治疗前,2组血清IL-10、IL-13、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组血清IL-10水平较治疗前明显升高(P<0.05),IL-13、TNF-α水平较治疗前明显降低(P<0.05);且治疗组IL-10水平明显高于对照组(P<0.05),IL-13、TNF-α水平明显低于对照组(P<0.05)。治疗前,2组ICAM-1、Eotaxin水平比较,差异无统计学意义(P>0.05);治疗后,2组ICAM-1、Eotaxin水平较治疗前明显降低(P<0.05),且治疗组2项指标均明显低于对照组(P<0.05)。结论:定喘汤配合常规西药治疗CVA患者疗效显著,可有效改善患者肺功能,减轻炎症反应,下调外周血ICAM-1、Eotaxin水平。Objective:To observe the clinical effect of Dingchuan tang combined with routine western medicine for cough variant asthma(CVA)and its effect on intercellular cell adhesion molecule-1(ICAM-1)and eosinophil activated chemokine Eotaxin levels in serum.Methods:A total of 76 cases of CVA patients were divided into the treatment group and the control group according to the random number table method,with 38 cases in each group respectively.The control group was treated with routine western medicine,and the treatment group was additionally treated with Dingchuan tang based on the treatment of the control group.Both groups were treated for one course,with eight weeks being one course.After one treatment course,clinical effects,the lung function indexes[forced vital capacity(FVC),the forced expiratory volume in one second(FEV_(1)),the ratio of forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC)],levels of tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)and interleukin-13(IL-13)in serum,and levels of ICAM-1 and Eotaxin in peripheral blood were evaluated in the two groups.Results:The total effective rate was 92.11%in the treatment group and 73.68%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of FVC,FEV_(1),and FEV_(1)/FVC between the two groups(P>0.05);after treatment,the above lung function indexes in the two groups were significantly increased when compared with those before treatment(P<0.05),and each index in the treatment group was significantly higher than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IL-10,IL-13 and TNF-αin serum between the two groups(P>0.05);after treatment,serum IL-10 levels in the two groups were significantly increased when compared with those before treatment(P<0.05),and levels of IL-13 and TNF-αin serum were significantly decreased(P<0.05);IL-10 level in the treatment gro

关 键 词：咳嗽变异性哮喘 定喘汤 炎症因子 细胞间黏附分子 嗜酸细胞活化趋化因子 

分 类 号：R562.25[医药卫生—呼吸系统]