脂肪干细胞免疫调节效应的应用研究进展  

Research progress on application of adipose stem cell immunomodulation

作　　者：黄天宇 孙恒赟 蒋海越 Huang Tianyu;Sun Hengyun;Jiang Haiyue(Department of Auricular Reconstruction,Plastic Surgery Hospital and Institute,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院耳再造中心,100144

出　　处：《中华整形外科杂志》2021年第12期1415-1419,共5页Chinese Journal of Plastic Surgery

基　　金：中国医学科学院医学与健康科技创新工程(2017-I2M-1-007);中国医学科学院北京协和医学院协和青年科研基金项目(3332015204)。

摘　　要：脂肪干细胞(ASC)具有良好的免疫调节作用,在血管化同种异体复合组织移植、自体脂肪移植、创面愈合等修复重建领域中有潜在免疫调节应用价值。该文通过回顾相关文献,讨论了ASC的静脉注射、腹腔注射、局部注射以及外泌体注射等不同给药方式的特点及应用条件,为ASC免疫调节进一步应用提供参考。Since adipose stem cells(ASC)have a good immunomodulatory capacity,ASCs have great potential in immunoregulation in vascularized composite allotransplantation,autologous fat transplantation and wound healing of repair and reconstructive surgery.By reviewing the relevant literatures,we discussed the characteristics and application conditions of various ASCs administrations including intravenous injection,intraperitoneal injection,local injection and exosome injection,so as to provide a reference for the further research and application of ASCs based on its immunomodulatory capacity.

关 键 词：间质干细胞 脂肪组织 免疫调节 投药途径 注射 静脉内 注射 病灶内 注射 腹腔内 外泌体 

分 类 号：R392[医药卫生—免疫学]