Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets  

作　　者：Divya S.Parimi Yamini Gupta Sreekar Marpu Chandra S.Bhatt Tharun K.Bollu Anil K.Suresh 

机构地区：[1]Bionanotechnology&Sustainable Laboratory,Department of Biological Sciences,School of Engineering and Applied Sciences,Sri Ramaswamy Memorial(SRM)University,Amaravati,522503,India [2]Department of Chemistry,University of North Texas,Denton,TX,76201,USA [3]Department of Biotechnology,Faculty of Science and Humanities,Sri Ramaswamy Memorial(SRM)Institute of Science and Technology,Chennai,603203,India

出　　处：《Journal of Pharmaceutical Analysis》2022年第3期365-379,共15页药物分析学报（英文版）

基　　金：Department of Science and Technology,Government of India,NewDelhi,for financial support through Early Career Research Award(Grant No.:ECR/2017/000339).

摘　　要：Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response analysis.Nanovectors of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility properties.In addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic approaches.Post-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are highlighted.SPION parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are discussed.We also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of toxins.Finally,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is reviewed.In summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.

关 键 词：NANOMAGNETS Biomimetics Utrasmall-SPIONs MAGNETIZATION Core-fusion Cancer theragnostics 

分 类 号：R917[医药卫生—药物分析学] R73[医药卫生—药学]