难治性肺炎支原体肺炎患儿凝血功能变化及检测意义  

Changes and detection significance of coagulation function in children with refractory Mycoplasma pneumoniae pneumonia

作　　者：周春 徐湘 傅俊健 居峰 ZHOU Chun;XU Xiang;FU Junjian;JU Feng(Department of Pediatrics,Jianhu Clinical Medical College of Yangzhou University,Jiangsu Province,Yangzhou 224700,China;Department of Laboratory,Jianhu Clinical Medical College of Yangzhou University,Jiangsu Province,Yangzhou 224700,China)

机构地区：[1]扬州大学建湖临床医学院儿科,江苏扬州224700 [2]扬州大学建湖临床医学院检验科,江苏扬州224700

出　　处：《妇儿健康导刊》2022年第6期50-53,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：江苏省盐城市医学科技发展计划项目(YK2019079)。

摘　　要：目的探讨难治性肺炎支原体肺炎患儿凝血功能变化及检测意义。方法回顾性选择2020年1月至2021年12月扬州大学建湖临床医学院儿科收治的50例难治性肺炎支原体肺炎患儿作为难治组,普通肺炎支原体肺炎患儿50例作为普通组,另选择同时间段收治的50例健康体检儿童作为对照组,三组接受凝血功能各指标检测,比较三组检测结果,另比较难治组患儿不同肺炎支原体抗体滴度的检测结果。结果难治组和普通组的纤维蛋白原(FIB)、D-二聚体(D-D)、国际标准化比值(INR)高于对照组,血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原活动度(PT%)低于对照组(P<0.05);难治组的FIB、D-D高于普通组,PT、APTT低于普通组(P<0.05)。1∶1280、1∶640滴度患儿的FIB、D-D高于其他两组,PT、APTT低于其他两组,且1∶320与1∶160滴度FIB、D-D、PT、APTT比较,差异有统计学意义(P<0.05)。难治组患儿凝血相关并发症总发生率为14.00%,高于普通组的2.00%,差异有统计学意义(P<0.05)。结论难治性肺炎支原体肺炎患儿的多项凝血功能指标异常,而且病情程度和感染程度越严重,凝血功能异常越明显,凝血相关并发症风险越高,研究价值较高。Objective To explore the coagulation function changes and detection significance in children with refractory Mycoplasma pneumoniae pneumonia.Methods A total of 50 children with refractory Mycoplasma pneumoniae pneumonia admitted to the Department of Pediatrics,Jianhu Clinical Medical College of Yangzhou University from January 2020 to December 2021 were retrospectively selected as the refractory group,50 children with common Mycoplasma pneumoniae pneumonia were selected as the normal group,and 50 healthy children who underwent physical examination in the same time period were selected as the control group.The coagulation function indexes were tested in the three groups,the test results of the three groups were compared,and the test results of different Mycoplasma pneumoniae antibody titers in the refractory group were compared.Results The fibrinogen(FIB),D-dimer(D-D),international normalized ratio(INR)of the refractory group and the normal group were higher than those of the control group,plasma prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin activity(PT%)were lower than those in the control group(P<0.05).The FIB and D-D of the refractory group were higher than those of the normal group,and the PT and APTT were lower than those of the normal group(P<0.05).The FIB and D-D of the children with titers of 1∶1280 and 1∶640 were higher than those of the other two groups,PT and APTT were lower than those of the other two groups,and the differences between 1∶320 and 1∶160 titers in FIB,D-D,PT,and APTT were statistically significant(P<0.05).The total incidence of coagulation-related complications in the refractory group was 14.00%,which was higher than that in the normal group(2.00%),and the difference was statistically significant(P<0.05).Conclusion Multiple coagulation indexes are abnormal in children with refractory Mycoplasma pneumoniae pneumonia,and the more serious the disease degree and infection degree,the more obvious the coagulation abnormalities,the higher

关 键 词：难治性肺炎支原体肺炎 抗体滴度 凝血功能 

分 类 号：R563.1[医药卫生—呼吸系统]