载脂蛋白基因多态性与动脉粥样硬化性心血管疾病的研究进展  

Research Progress of Apolipoprotein Gene Polymorphism and Atherosclerotic Cardiovascular Diseases

作　　者：王小婉 李欣宇 徐康媛 单琳琳 李超堃[1] WANG Xiaowan;LI Xinyu;XU Kangyuan;SHAN Linlin;LI Chaokun(School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China;Key Lab of Biological Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 435002,China)

机构地区：[1]新乡医学院基础医学院,河南新乡453003 [2]新乡医学院第二附属医院生物精神病学重点实验室,河南新乡453002

出　　处：《医学综述》2022年第12期2320-2325,共6页Medical Recapitulate

基　　金：河南省科技攻关项目(222102310708);河南省生物精神病学重点实验室开放课题(ZDSYS2020004);河南省自然科学基金(222300420515)。

摘　　要：血脂异常是动脉粥样硬化性心血管疾病的主要危险因素。影响血脂异常代谢的因素包括环境因素(如长期摄入大量饱和脂肪酸、胆固醇、碳水化合物)和基因座遗传因素。其中,载脂蛋白(Apo)基因突变与血脂紊乱密切相关。Apo是脂蛋白的重要组成部分,能够结合并运输脂质至机体各组织进行代谢及利用。目前已鉴定出20多种Apo亚型,包括ApoA、ApoB、ApoC、ApoD、ApoE、ApoH、ApoM等。这些不同亚型的Apo基因存在多种突变类型。未来根据Apo家族各基因多态性的分布确定潜在的治疗靶点,可为临床心血管疾病的治疗提供新思路。Dyslipidemia is a main risk factor for atherosclerotic cardiovascular disease.The causes of dyslipidemia include not only environmental factors,such as long-term intake of saturated fatty acids,cholesterol and carbohydrate,but also locus genetic factors.Among them,apolipoprotein(Apo)gene mutation is closely related to dyslipidemia.Apo is an important component of lipoprotein,which can bind and transport lipids to various tissues of the body for metabolism and utilization.So far,more than 20 forms of Apo subtypes have been identified,including ApoA,ApoB,ApoC,ApoD,ApoE,ApoH,ApoM and so on.There are many types of mutations in these different subtypes of Apo genes.In the future,identifying potential therapeutic targets according to the distribution of Apo family gene polymorphisms can provide new ideas for the treatment of clinical cardiovascular diseases.

关 键 词：动脉粥样硬化 载脂蛋白 单核苷酸多态性 脂质代谢 

分 类 号：R54[医药卫生—心血管疾病] R743[医药卫生—内科学]