miR-155对变应性鼻炎患者ILC2转录因子GATA3调控作用的研究进展  

Research progress in the regulation of miR-155 on the transcription factor GATA3 of ILC2 in allergic rhinitis patients

作　　者：黄雪颖 李荣荣 张少杰[1] 唐凤珠(综述)[1] 瞿申红(审校)[1] HUANG Xue-ying;LI Rong-rong;ZHANG Shao-jie(Department of Otorhinolaryngology Head and Neck,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Graduate School,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院耳鼻咽喉头颈科,南宁530021 [2]广西医科大学研究生院,南宁530021

出　　处：《中国临床新医学》2022年第6期562-565,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:81960816)。

摘　　要：Ⅱ型固有免疫细胞(ILC2)受刺激后可产生Th2型细胞因子,促进变应性鼻炎(AR)迟发相反应。miR-155在免疫系统的发育、免疫细胞的成熟分化以及维持免疫功能中都发挥至关重要的作用。GATA结合蛋白3(GATA3)是能够促进ILC2发育成熟的转录因子,而在肿瘤研究中,GATA3是miR-155的靶基因。该文对参与AR鼻黏膜中的ILC2转录因子GATA3及可干扰其表达的miR-155作一综述。TypeⅡinnate lymphoid cells(ILC2)are stimulated to produce T-helper lymphocyte type 2(Th2)cytokines,which promote late phase reaction in allergic rhinitis(AR).Micro ribonucleic acid-155(microRNA-155,miR-155)plays a crucial role in the development of the immune system,the maturation and differentiation of immune cells and the maintenance of immune function.GATA binding protein 3(GATA3)is a transcription factor that can promote the development and maturation of ILC2,and in tumor research,GATA3 is the target gene of miR-155.In this paper,we mainly review the transcription factor GATA3 of ILC2 which is involved in AR in nasal mucosa and miR-155 which can interfere with GATA3 expression.

关 键 词：变应性鼻炎 Ⅱ型固有免疫细胞 GATA结合蛋白3 microRNA-155 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]