显微手术治疗脑血管畸形患者的效果  

Effect of Microsurgery in the Treatment of Cerebrovascular Malformations Patients

作　　者：张辉喜 ZHANG Huixi(Changde City No.1 Hospital of Traditional Chinese Medicine,Hunan Province,Changde 415000,China)

机构地区：[1]湖南省常德市第一中医医院,湖南常德415000

出　　处：《中国医学创新》2022年第18期102-105,共4页Medical Innovation of China

摘　　要：目的:研究显微手术对脑血管畸形的患者美国国立卫生院神经功能缺损评分(NIHSS)、日常生活活动能力量表(Barthel指数)及血清海马组织水通道蛋白4(AQP4)、基质金属蛋白酶-9(MMP-9)、Toll样受体4(TLR4)水平的影响。方法:回顾性分析2020年3月-2021年2月在常德市第一中医医院进行治疗的100例脑血管畸形患者的临床资料,根据手术差异将其分为观察组和对照组,每组50例。对照组开展常规血管切除术治疗,观察组则开展显微手术治疗。比较两组手术前后的NIHSS评分、Barthel指数、血清AQP4、MMP-9、TLR4水平;比较两组临床疗效及不良结局发生情况。结果:术后,两组NIHSS评分均低于术前,而Barthel指数均高于术前,但观察组NIHSS评分低于对照组,Barthel指数高于对照组,差异均有统计学意义(P<0.05)。术后,观察组血清AQP4、MMP-9及TLR4水平均低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。观察组不良结局发生率低于对照组,差异有统计学意义(P<0.05)。结论:对脑血管畸形患者开展显微手术治疗的效果显著,有利于改善NIHSS、Barthel指数及血清AQP4、MMP-9、TLR4水平,提高治疗效果,减少不良结局,值得推广。Objective:To investigate the effect of microsurgery on NIHSS,Barthel index and the levels of aquaporin 4 in serum hippocampal tissue(AQP4),matrix metalloproteinase-9(MMP-9)and Toll-like receptor 4(TLR4)of patients with cerebrovascular malformation.Method:The data of 100 patients with cerebrovascular malformation treated in Changde City No.1 Hospital of Traditional Chinese Medicine from March 2020 to February 2021 were retrospectively analyzed,they were divided into observation group and control group according to operation differences,50 cases in each group.The control group was treated with conventional vasectomy,and the observation group was treated with microsurgery.NIHSS score,Barthel index,serum AQP4,MMP-9 and TLR4 levels before and after operation were compared between two groups;the clinical efficacy and incidence of adverse outcomes were compared between two groups.Result:After operation,NIHSS scores in both groups were lower than those before operation,and Barthel indexes in both groups were higher than those before operation,but NIHSS score in the observation group was lower than that in the control group,and Barthel index in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).After operation,the serum AQP4,MMP-9 and TLR4 levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse outcomes in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Microsurgical treatment for patients with cerebrovascular malformation has a significant effect,which is beneficial to improve NIHSS,Barthel index and serum AQP4,MMP-9,TLR4 levels,improve the treatment efficiency and reduce the occurrence of adverse outcomes,which is worthy of popularizati

关 键 词：显微手术 脑血管畸形 美国国立卫生院神经功能缺损评分 日常生活活动能力量表指数 

分 类 号：R651.12[医药卫生—外科学]