滴制法制备白藜芦醇固体分散体  

Preparation of Resveratrol Solid Dispersions by Dropping Method

作　　者：徐凤男 苏洁 王春雨 王建文 朱仁杰 肖若蕾[1] XU Feng-nan;SU Jie;XIAO Ruo-lei(School of Pharmacy,Xianning Medical College,Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]湖北科技学院医学部药学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2022年第3期207-211,共5页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北科技学院药学重点学科专项科研项目(2019-20YZ20)。

摘　　要：目的改善白藜芦醇的溶出性能。方法利用溶剂—熔融—滴制法制备白藜芦醇固体分散体,以溶出度和成型性为评价指标,考察载体种类、复合载体材料质量比、药物与载体的质量比,筛选出最优处方,并通过傅里叶变换红外光谱(FTIR)、差示扫描量热法(DSC)和X射线衍射法(XRD)技术对最优处方进行物相鉴定。结果白藜芦醇固体分散体的最佳处方为:复合基质P188与PEG4000的质量比为1∶9,药载比为1∶10。白藜芦醇固体分散体在60min时的体外溶出度较原料药明显提高,FTIR、XRD和DSC结果显示白藜芦醇在载体材料中以无定形形式存在。结论采用滴制法制备白藜芦醇固体分散体,能有效改善其溶出性能。Objective To prepare solid dispersions with the dropping method for improvement of resveratrol solubility.Methods Solid dispersions of resveratrol were prepared by the solvent-melt-drop methods.The carrier type,the mass ratio of composite carrier material and the drugcarrier ratio were all investigated by using dissolution and formability as evaluation indexes,and the optimal prescription was obtained.Fourier transform infrared spectroscopy(FTIR),differential scanning calorimetry(DSC)and Xray diffraction(XRD)were used to identify the phases of resveratrol.Results The optimal prescription of resveratrol solid dispersions was that the mass ratio of P188 to PEG4000 was 1∶9,and the drug loading ratio was 1∶10.The results of FTIR,XRD and DSC showed that resveratrol was highly dispersed in the carrier material with amorphous form.The dissolution rate of resveratrol solid dispersions was significantly higher than that of resveratrol raw material within 60min.Conclusion Solid dispersions of resveratrol prepared by the dropping method could effectively improve the solubility of resveratrol.

关 键 词：白藜芦醇 固体分散体 溶出度 聚乙二醇4000 泊洛沙姆188 

分 类 号：R943[医药卫生—药剂学]