吸入用布地奈德混悬液缓解成人支气管哮喘急性发作的疗效分析  

Efficacy analysis of budesonide suspension for inhalation in relieving acute exacerbation of bronchial asthma in adults

作　　者：肖祖琳 XIAO Zu-lin(Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,China)

机构地区：[1]辽宁省大连大学附属中山医院,116001

出　　处：《中国实用医药》2022年第12期106-108,共3页China Practical Medicine

摘　　要：目的 研究吸入用布地奈德混悬液缓解成人支气管哮喘急性发作的疗效。方法 100例成人支气管哮喘急性发作患者,根据治疗方式不同分为实验组与对照组,每组50例。对照组采用沙丁胺醇雾化吸入治疗,实验组在对照组的基础上增加吸入用布地奈德混悬液进行联合治疗。比较两组临床症状消失时间、住院时间、肺功能指标、血气分析指标、治疗效果、哮喘发作次数。结果 实验组喘息消失时间(3.66±1.55)d、哮鸣音消失时间(3.30±1.10)d、咳嗽消失时间(5.29±1.32)d及住院时间(5.79±1.11)d短于对照组(5.57±1.59)、(6.10±1.46)、(7.58±1.42)、(8.46±1.13)d,差异有统计学意义(P<0.05)。治疗后,实验组用力肺活量(FVC)、第1秒内用力呼气容积(FEV1)、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))均优于对照组,差异有统计学意义(P<0.05)。实验组总有效率96.00%高于对照组的84.00%,差异有统计学意义(P<0.05)。实验组患者白天、夜间哮喘发作次数分别为(1.25±0.84)、(0.47±0.11)次少于对照组的(3.55±1.09)、(1.49±0.75)次,差异有统计学意义(P<0.05)。结论 采用吸入用布地奈德混悬液对支气管哮喘急性发作的成人患者进行治疗能够获得更加理想的疗效,具有较高的安全性。Objective To study the efficacy of budesonide suspension for inhalation in relieving acute exacerbation of bronchial asthma in adults.Methods A total of 100 adult patients with acute exacerbation of bronchial asthma were divided into experimental group and control group according to different treatment methods,with 50 cases in each group.The control group was treated with salbutamol nebules inhalation,and the experimental group was additionally treated with budesonide suspension for inhalation on the basis of the treatment of the control group.The clinical symptom disappearance time,hospitalization time,pulmonary function index,blood gas analysis index,therapeutic effect and frequency of asthma attack were compared between the two groups.Results The disappearance time of dyspnea(3.66±1.55)d,disappearance time of wheezing(3.30±1.10)d,disappearance time of cough(5.29±1.32)d and hospitalization time(5.79±1.11)d in the experimental group were shorter than(5.57±1.59),(6.10±1.46),(7.58±1.42),and(8.46±1.13)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the 1st second(FEV1),arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))of the experimental group were better than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate 96.00%of the experimental group was higher than 84.00%of the control group,and the difference was statistically significant(P<0.05).The frequency of asthma attacks during the day and night in the experimental group were(1.25±0.84)and(0.47±0.11)attacks/d,which were less than(3.55±1.09)and(1.49±0.75)attacks/d in the control group,and the difference was statistically significant(P<0.05).Conclusion Budesonide suspension for inhalation in the treatment of adult patients with acute exacerbation of bronchial asthma can achieve better efficacy and have higher safety.

关 键 词：支气管哮喘急性发作 吸入用布地奈德混悬液 沙丁胺醇 临床疗效 不良反应 

分 类 号：R562.25[医药卫生—呼吸系统]