中医五行音乐疗法联合疏肝健脾方治疗肝郁脾虚型糖尿病合并抑郁症的疗效观察  

Clinical Value of Five-Element Music Therapy Combined with Shugan Jianpi Prescription in the Treatment of Diabetes Complicated with Depression(Syndrome of Liver Depression and Spleen Deficiency)

作　　者：张冬冬 毕菲菲 ZHANG Dong-dong;BI Fei-fei(Third Department of Endocrinology,Tangshan Hospital of Traditional Chinese Medicine,TangshanHebei 063000;First Department of Endocrinology,Tangshan Hospital of Traditional Chinese Medicine,TangshanHebei 063000)

机构地区：[1]唐山市中医医院内分泌三科,河北唐山063000 [2]唐山市中医医院内分泌一科,河北唐山063000

出　　处：《世界中西医结合杂志》2022年第5期917-921,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局项目课题(2021388)。

摘　　要：目的探讨中医五行音乐疗法联合疏肝健脾方在肝郁脾虚型糖尿病合并抑郁症患者中应用价值。方法选取2018年9月—2020年9月期间于唐山市中医医院治疗的180例肝郁脾虚型糖尿病合并抑郁症患者,按简单随机化法分为对照组、治疗1组、治疗2组,每组各60例。在降糖治疗的基础上,3组患者分别给予草酸艾司西酞普兰、疏肝健脾方、中医五行音乐疗法+疏肝健脾方治疗。治疗6周后,观察比较3组患者中医疗效、不良反应及治疗前后中医证候积分(精神抑郁、胁肋胀痛、倦怠乏力)、血糖水平[空腹血糖(Fasting plasma glucose,FPG)、餐后2 h血糖(2 hour postprandial glucose,2 h PG)]、抑郁程度[汉密尔顿抑郁量表17项(Hamilton depression scale-17,HAMD-17)评分]。结果治疗6周后,治疗2组、治疗1组总有效率分别为93.33%(56/60)、89.83%(53/59)明显高于对照组,差异有统计学意义(P<0.05),治疗1组和治疗2组治疗总有效率比较,差异无统计学意义(P>0.05)。治疗6周后3组患者精神抑郁、倦怠乏力、胁肋胀痛评分均低于治疗前,差异有统计学意义(P<0.05);且治疗2组、治疗1组精神抑郁、倦怠乏力、胁肋胀痛评分均明显低于对照组,差异有统计学意义(P<0.05),治疗2组精神抑郁评分明显低于治疗1组,差异有统计学意义(P<0.05)。治疗6周后3组患者FPG、2 h PG水平及HAMD-17评分均明显低于治疗前,差异有统计学意义(P<0.05);且治疗2组、治疗1组FPG、2 h PG水平及HAMD-17评分明显低于对照组,差异有统计学意义(P<0.05),治疗2组HAMD-17评分明显低于治疗1组,差异有统计学意义(P<0.05)。3组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论中医五行音乐疗法联合疏肝健脾方可控制肝郁脾虚型糖尿病合并抑郁症患者血糖,减轻抑郁程度,提高治疗效果,且具有一定安全性。Objective To explore the clinical value of five-element music therapy combined with Shugan Jianpi Prescription in treating diabetes complicated with depression(syndrome of liver depression and spleen deficiency).Methods A total of 180 patients of diabetes complicated with depression(syndrome of liver depression and spleen deficiency)who were treated in Tangshan Hospital of Traditional Chinese Medicine from September 2018 to September 2020 were selected and assigned into a control group(60 patients),observation group 1(60 patients),and observation group 2(60 patients)by simple randomization method.On the basis of hypoglycemic therapy,the above three groups received escitalopram oxalate,Shugan Jianpi Prescription,and five-element music therapy+Shugan Jianpi Prescription,respectively.The treatments in all the groups lasted for six weeks,and then the TCM efficacy was compared between groups.The adverse reactions were recorded during treatment.The TCM syndrome scores(mental depression,flank pain,and fatigue),fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 h PG),and Hamilton Depression Scale-17(HAMD-17)score were compared between before treatment and after treatment as well as between the three groups.Results During thetreatment,2 cases in the control group were excluded due to poor medication compliance,and 1 case in the observation group 1 was lost to follow-up for no clear reason and was determined to be a dropout.After six weeks of treatment,the total effective rates in the observation groups 2 and 1 were 93.33%(56/60)and 89.83%(53/59),respectively,which had no significant difference between each other(P>0.05)and were higher than that in the control group(P<0.05).The six weeks of treatment in all the three groups decreased the scores of mental depression,fatigue,and flank pain compared with those before treatment(P<0.05).Moreover,the scores were the lowest in the observation group 2,moderate in the observation group 1,and the highest in the control group,with significant differences(P<0.05).FPG,2 h

关 键 词：糖尿病 抑郁症 肝郁脾虚型 疏肝健脾方 中医五行音乐疗法 

分 类 号：R587.1[医药卫生—内分泌]