G蛋白偶联受体在肾脏疾病中的作用机制研究进展  

Recent advances on the role of G-protein-coupled receptors in kidney diseases

作　　者：王晓杰[1] 崔晓阳 褚晴晴 李羽佳 吕航 易凡[1] Wang Xiaojie;Cui Xiaoyang;Chu Qingqing;Li Yujia;Lu Hang;Yi Fan(School of Basic Medicine Sciences,Shandong University,Jinan 250012,Shandong,China)

机构地区：[1]山东大学基础医学院,山东济南250012

出　　处：《生物医学转化》2022年第2期39-45,共7页Biomedical transformation

基　　金：国家自然科学基金(91949202,82090024,82170734)。

摘　　要：G蛋白偶联受体(G-Protein-Coupled Receptors,GPCRs)广泛表达于不同的细胞类型,参与众多细胞生物学功能的调控。研究显示,GPCRs介导的相关通路在维持肾脏发育、调节肾脏生理功能及在肾脏疾病发生发展中发挥重要作用。本综述简要阐述了GPCRs相关通路特点,并重点介绍黏附类GPCRs(adhesion GPCRs,aGPCRs)、大麻素受体(Cannabinoid Receptors,CB)、溶血磷脂酸受体(Lysophosphatidic Acid Receptor,LPAR)在肾脏疾病领域的最新研究进展,以期加深对GPCRs功能的认识,并为多种肾脏疾病治疗药物的开发提供思路。The G-protein-coupled receptors(GPCRs)are widely expressed in many cell types and participate in various cellular biological processes.Several studies have shown that GPCRs-mediated signaling pathways play significant roles in maintaining renal development,regulating renal physiological function,and in the pathogenesis of renal diseases.In this review,we have described the characteristics and function of GPCRs-related pathways,especially the adhesion GPCRs(aGPCRs),cannabinoid receptors(CB),and lysophosphatidic acid receptors(LPAR)in the field of kidney diseases.Hopefully,this review could enhance the understanding of GPCRs function and shed light on potential therapeutic targets for kidney disease treatment.

关 键 词：G蛋白偶联受体 肾脏疾病 黏附类G蛋白偶联受体 大麻素受体 溶血磷脂酸受体 

分 类 号：R692[医药卫生—泌尿科学] R363.21[医药卫生—外科学]