急性加重期慢性阻塞性肺疾病患者SAA、MYD88及纤维蛋白原的水平及相关性  

Correlation analysis of SAA,MyD88 and fibrinogen in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：缪冬冬[1] 崔芳芳 张传红 MIAO Dong-Dong;CUI Fang-Fang;ZHANG Chuan-Hong(Department of Emergency,Traditional Chinese Medicine Hospital of Pukou District in Nanjing City,Nanjing 211800,Jiangsu,China)

机构地区：[1]南京市浦口区中医院,江苏南京211800

出　　处：《吉林医学》2022年第4期878-881,共4页Jilin Medical Journal

摘　　要：目的:探讨急性加重期慢性阻塞性肺疾病(COPD)患者SAA、MYD88及纤维蛋白原的水平及相关性。方法:选取2018年11月~2019年11月于南京市浦口区中医院收治的COPD患者104例,其中COPD稳定期患者54例、COPD急性加重患者50例,另随机选取同期在院接受体检的健康志愿者60例为健康对照组。使用酶联免疫吸附试验检测淀粉样蛋白A(SAA)表达,Western印迹检测髓系分化因子(MYD)88表达,应用自动血凝分析仪检测纤维蛋白原(Fbg)。结果:COPD稳定组、COPD急性加重组SAA表达高于健康对照组,且COPD急性加重组SAA表达高于COPD稳定组,差异有统计学意义(P<0.05)。COPD稳定组、COPD急性加重组MYD88表达高于健康对照组,且COPD急性加重组高于COPD稳定组,差异有统计学意义(P<0.05)。COPD稳定组、COPD急性加重组Fbg表达高于健康对照组,且COPD急性加重组高于COPD稳定组,差异有统计学意义(P<0.05)。结论:SAA、MYD88及Fbg在临床上针对COPD的预估有着重要价值,能够准确预估炎症反应情况,对COPD的临床治疗有着积极意义。Objective To explore the relationship between SAA,MyD88 and fibrinogen in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Method From November 2018 to November 2019,104 patients with COPD were enrolled in our hospital,including 54 patients with COPD in stable period and 50 patients with COPD in acute aggravation.In addition,60 healthy volunteers who received physical examination in our hospital at the same time were randomly selected as healthy control group.The expression of amyloid A(SAA)was detected by enzyme-linked immunosorbent assay,MyD88 by Western blot,and fibrinogen(Fbg)by automatic hemagglutination analyzer.Results Compared with the healthy control group,the expression of SAA in COPD stable group,COPD acute plus recombinant group was higher than that of healthy control group,and that of COPD acute plus recombinant group was higher than that of COPD stable group(P<0.05).Compared with healthy control group,the expression of MyD88 in COPD stable group,COPD acute plus recombinant group was higher than that of healthy control group,and that of COPD acute plus recombinant group was higher than that of COPD stable group.Compared with healthy control group,the expression of Fbg in COPD group was higher than that of healthy control group,and the expression of recombinant fibrinogen in COPD group was higher than that in COPD group(P<0.05).Conclusion In clinical practice,acupuncture has an important value in the prediction of chronic obstructive pulmonary disease,can accurately predict the inflammatory response,and has a positive significance in the clinical treatment of chronic obstructive pulmonary disease.

关 键 词：慢性阻塞性肺疾病 淀粉样蛋白A 髓系分化因子88 纤维蛋白原 

分 类 号：R563.9[医药卫生—呼吸系统]