氨基葡萄糖联合关节腔注射自体富血小板血浆治疗膝关节骨性关节炎的临床观察  

Clinical Observation of Glucosamine Combined with Intra-articular Injection of Autologous Platelet-rich Plasma in the Treatment of Knee Osteoarthritis

作　　者：崔瑞开 李松生 尤笑迎[1] CUI Ruikai;LI Songsheng;YOU Xiaoying(The Third Department of Orthopedics, Zhengzhou People’s Hospital, Zhengzhou Henan 450000,China)

机构地区：[1]郑州人民医院骨三科,郑州450000

出　　处：《河南医学高等专科学校学报》2022年第3期274-278,共5页Journal of Henan Medical College

摘　　要：目的探讨氨基葡萄糖联合关节腔注射自体富血小板血浆(platelet-rich plasma,PRP)对膝关节骨性关节炎(knee osteoarthritis,KOA)患者Lysholm评分、关节液基质金属蛋白酶-3(matrix metalloproteinase 3,MMP-3)、关节液金属蛋白酶抑制剂-1(tissue inhibitors of metalloproteinase 1,TIMP-1)水平及数字评定量表(numeric rating scale,NRS)评分的影响。方法选取94例KOA患者,依据随机数字表法分为观察组(氨基葡萄糖联合自体PRP关节腔注射治疗)与对照组(单纯服用氨基葡萄糖治疗),各47例。比较2组临床疗效、Lysholm评分、MMP-3水平、TIMP-1水平及NRS评分。结果观察组总有效率93.62%,高于对照组的76.60%,差异有统计学意义(P<0.05)。治疗前,2组患者Lysholm评分差异无统计学意义(P>0.05);治疗后,2组Lysholm评分均较治疗前升高,且观察组高于对照组[(80.25±10.68)分vs(66.42±9.31)分],差异有统计学意义(P<0.05)。治疗前,2组患者关节液MMP-3、TIMP-1水平差异无统计学意义(P>0.05);治疗后,2组关节液MMP-3、TIMP-1水平均较治疗前改善,且观察组改善情况均优于对照组,差异有统计学意义(P<0.05)。治疗前,2组患者NRS评分差异无统计学意义(P>0.05);治疗后,2组患者NRS评分均较治疗前下降,且观察组低于对照组[(1.91±0.74)分vs(3.26±1.37)分],差异有统计学意义(P<0.05)。结论对KOA患者实施氨基葡萄糖联合自体PRP关节腔注射治疗,其临床疗效优于单用氨基葡萄糖治疗,可改善患者膝关节功能,减轻关节疼痛,对关节液MMP-3、TIMP-1水平起到有效调节作用。Objective To investigate the effect of glucosamine combined with intra-articular injection of autologous platelet-rich plasma(PRP)on Lysholm score,synovial fluid matrix metalloproteinase 3(MMP-3),the level of tissue inhibitors of metalloproteinase 1(TIMP-1)in synovial fluid and the score of numerical rating scale(NRS)in patients with knee osteoarthritis(KOA).Methods A total of 94 patients with KOA were selected and randomly divided into an observation group(treated with glucosamine combined with autologous PRP intra-articular injection)and a control group(treated with glucosamine alone),47 cases in each group.The clinical efficacy,Lysholm score,MMP-3 level,TIMP-1 level and NRS score were compared between the two groups.Results The total effective rate in the observation group was 93.62%,which was higher than 76.60%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in Lysholm scores between the two groups(P>0.05);after treatment,the Lysholm scores of the two groups were both higher than those before treatment,and the observation group was higher than the control group[(80.25±10.68)points vs(66.42±9.31)points],the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of MMP-3 and TIMP-1 in the synovial fluid between the two groups(P>0.05);after treatment,the levels of MMP-3 and TIMP-1 in the synovial fluid in the two groups were improved compared with those before treatment,especially in the observation group,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference in NRS scores between the two groups(P>0.05);after treatment,the NRS scores in both groups decreased compared with those before treatment,and the observation group decreased more significantly than the control group[(1.91±0.74)points vs(3.26±1.37)points],and the difference was statistically significant(P<0.05).Conclusion The clinical ef

关 键 词：膝关节骨性关节炎 氨基葡萄糖 自体富血小板血浆 膝关节功能 

分 类 号：R684[医药卫生—骨科学]