疫苗制品中抑菌剂去除研究进展  

Research progress on the removal of antimicrobial agents in vaccine products

作　　者：朱德武 瞿明霞 闫亚楠 姜崴 李景良 付博 张飞伟[3] 杨勇[3] 张锐[3] 王晓娟[4] 孟丽 杨汇川 吴永林 潘海龙 ZHU Dewu;QU Mingxia;YAN Yanan;JIANG Wei;LI Jingliang;FU Bo;ZHANG Feiwei;YANG Yong;ZHANG Rui;WANG Xiaojuan;MENG Li;YANG Huichuan;WU Yonglin;PANG Hailong(Wuhan Institute of Biological Products Co.,Ltd.,Wuhan 430207,China;Changchun Institute of Biological Products Co.,Ltd.,Changchun 130015,China;Chengdu Institute of Biological Products Co.,Ltd.,Chengdu 130015,China;Chinese Pharmacopoeia Commission,Beijing 100020,China;China Biotechnology Corporation,Beijing 100029,China)

机构地区：[1]武汉生物制品研究所有限责任公司,武汉430207 [2]长春生物制品研究所有限责任公司,长春130015 [3]成都生物制品研究所有限责任公司,成都610023 [4]国家药典委员会,北京1000205 [5]中国生物技术股份有限公司,北京100024

出　　处：《中国药品标准》2022年第3期236-240,共5页Drug Standards of China

基　　金：国家药典委员会药品标准制修订研究课题(2020S03)。

摘　　要：本文依托国家药典委员会药品标准制修订研究课题(2020S03),对中国药典已收载添加抑菌剂的单剂量液体疫苗去除抑菌剂的可行性开展了研究,根据研究结果评估去除抑菌剂的风险效益,为《中国药典》修订提供技术支持。Based on the research project of the Revision of Pharmaceutical Standards(2020 S03)of the Chinese Pharmacopoeia Commission,we carried out the feasibility of the removal antimicrobial agents from single-dose liquid vaccine admitted in the Chinese Pharmacopoeia.According to the results,the risk-benefit of antimicrobial agents was evaluated,and technical support for the revision of the Chinese Pharmacopoeia was provided.

关 键 词：抑菌剂 硫柳汞 苯酚 单剂量 疫苗 

分 类 号：R921.2[医药卫生—药学]