逐瘀定喘汤联合针灸治疗慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study of Zhuyu Dingchuan Tang Combined with Acupuncture and Moxibustion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：王银菊 李文生 李琳琳 WANG Yinju;LI Wensheng;LI Linlin

机构地区：[1]濮阳市中医医院肺病科,河南濮阳457000

出　　处：《新中医》2022年第11期96-101,共6页New Chinese Medicine

摘　　要：目的:观察逐瘀定喘汤联合针灸治疗慢性阻塞性肺疾病急性加重期(AECOPD)痰瘀阻肺证的临床疗效。方法:选取80例AECOPD患者,按治疗方法不同分为对照组及观察组各40例。对照组接受现代医学常规治疗,观察组在对照组基础上加用逐瘀定喘汤联合针灸治疗,2组均连续治疗14 d。比较2组临床疗效,比较2组治疗前后中医证候积分、血清炎症因子[白细胞介素-6(IL-6)、C-反应蛋白(CRP)]、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1)),计算FEV_(1)/FVC]指标、血液流变学[血沉(ESR)、红细胞聚集指数(RAI)、红细胞压积(HCT)、血浆黏度(PV)、高切、低切]指标的变化,观察2组不良反应发生情况。结果:治疗后,观察组临床疗效总有效率为92.50%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清IL-6、CRP水平均较治疗前下降,观察组上述2项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组FVC、FEV_(1)/FVC指标值均较治疗前上升,观察组上述2项指标值均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组ESR、RAI、HCT、PV、高切、低切指标值均较治疗前下降,观察组上述6项指标值均低于对照组,差异均有统计学意义(P<0.05)。2组治疗期间均未发生明显不良反应。结论:逐瘀定喘汤联合针灸治疗AECOPD疗效确切,可有效提升肺功能,改善炎症症状,治疗方案安全性较高。Objective:To observe the clinical effect of Zhuyu Dingchuan tang combined with acupuncture and moxibustion for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm-stasis obstructing the lung syndrome.Methods:A total of 80 cases of AECOPD patients were selected and divided into the control group and the observation group according to different treatment methods,with 40 cases in each group.The control group was given routine modern medicine treatment,and the observation group was additionally treated with Zhuyu Dingchuan tang combined with acupuncture and moxibustion based on the treatment of the control group.Both groups were continuously treated for 14 days.Clinical effects were compared between the two groups.The changes in Chinese medicine syndrome scores,serum inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP)],indexes of lung function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1)),FEV_(1)/FVC],and indexes of hemorheology[erythrocyte sedimentation rate(ESR),red cell aggregation index(RAI),hematocrit(HCT),plasma viscosity(PV),high shear and low shear]were compared between the two groups before and after treatment.The incidence of adverse reactions in the two groups was observed.Results:After treatment,the total effective rate of clinical effect was 92.50%in the observation group and75.00%in the control group,the difference being significant(P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,differences being significant(P<0.05).After treatment,levels of IL-6 and CRP in serum in the two groups were decreased when compared with those before treatment,and the two levels in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,values of FVC and FEV_(1)/FVC in the two groups were increased when compared with those before

关 键 词：慢性阻塞性肺疾病 急性加重期 痰瘀阻肺证 逐瘀定喘汤 针灸 

分 类 号：R563.9[医药卫生—呼吸系统]