扶正抗痨方联合四联疗法治疗气阴两虚型肺结核临床研究  

Clinical Study on Fuzheng Kanglao Prescription Combined with Quadruple Chemotherapy for Pulmonary Tuberculosis of Deficiency of Both Qi and Yin Type

作　　者：徐婧 武喜明 赵娣 XU Jing;WU Ximing;ZHAO Di

机构地区：[1]郑州市第六人民医院药学部,河南郑州450000

出　　处：《新中医》2022年第11期102-106,共5页New Chinese Medicine

摘　　要：目的:观察扶正抗痨方联合四联疗法治疗气阴两虚型肺结核的临床疗效。方法:选取112例气阴两虚型肺结核患者作为研究对象,按随机数字表法分为对照组50例及观察组62例,对照组给予常规四联疗法进行抗结核治疗,观察组在对照组基础上加用扶正抗痨方口服,2组均连续服用4周。比较2组临床疗效,比较2组治疗前后中医证候评分及炎性因子[血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)]、T细胞亚群指标的变化。结果:观察组临床疗效总有效率为90.32%,对照组总有效率为76.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候主症评分、次症评分及总积分均较治疗前下降(P<0.05),观察组中医证候主症评分、次症评分及总积分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清IL-6、TNF-α水平均较治疗前下降,IL-10水平均较治疗前上升,差异均有统计学意义(P<0.05);治疗后,观察组血清IL-6,TNF-α水平均低于对照组,IL-10水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组CD8^(+)水平均较治疗前下降,CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前上升,差异均有统计学意义(P<0.05);观察组CD8^(+)水平低于对照组,CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,差异均有统计学意义(P<0.05)。结论:扶正抗痨方联合四联疗法可有效减轻气阴两虚型肺结核患者的临床症状,提高疗效,减轻炎症反应。Objective:To observe the clinical effect of Fuzheng Kanglao prescription combined with quadruple chemotherapy for pulmonary tuberculosis of deficiency of both qi and yin type.Methods:A total of 112 cases of patients with pulmonary tuberculosis of deficiency of both qi and yin type were selected as the study subjects and divided into the control group and the observation group according to the random number table method,with 50 and 62 cases in each group respectively.The control group was treated with routine quadruple chemotherapy for anti-tuberculosis treatment,and the observation group was additionally given oral administration of Fuzheng Kanglao prescription based on the treatment of the control group.Both groups were treated for four weeks.The changes in Chinese medicine syndrome scores,inflammatory factors in serum including interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α),and T cell subsets indexes before and after treatment,and the clinical effects in the two groups were compared.Results:The total effective rate of clinical effect was 90.32%in the observation group and 76.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of main symptoms and secondary symptoms and the total scores in Chinese medicine syndromes in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of main symptoms and secondary symptoms and the total score in Chinese medicine syndromes in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the levels of IL-6and TNF-αin serum in the two groups were decreased when compared with those before treatment,and the IL-10 levels were increased,differences being significant(P<0.05).After treatment,the levels of IL-6 and TNF-αin serum in the observation group were lower than those in the control group,and the IL-10 level was higher,differences being significant(P<0.05).After treatment,the levels of CD8^(+)in the two group

关 键 词：肺结核 气阴两虚型 扶正抗痨方 炎性因子 免疫功能 

分 类 号：R521[医药卫生—内科学]