苦参碱治疗肝癌的研究进展  

Research Progress of Matrine in Treatment of Liver Cancer

作　　者：李振 王科 王凯强 俞科贤[2] LI Zhen;WANG Ke;WANG Kaiqiang;YU Kexian(Qinghai University,Xining 810016,Qinghai,China)

机构地区：[1]青海大学研究生院,青海西宁810016 [2]青海大学医学院,青海西宁810001

出　　处：《中华中医药学刊》2022年第4期99-103,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局全国中医药创新骨干人才培训项目(国中医药人教函[2019]128)。

摘　　要：苦参碱是豆科植物苦参的干燥根、植株、果实的有效成分。药理学研究发现苦参碱能够通过相关蛋白、相关信号通路、自噬及上皮细胞-间充质转化等多个途径抑制肝癌细胞的增殖、侵袭、迁移和诱导凋亡,从而发挥其拮抗肿瘤生长的作用。结合近年来国内外研究现状,对苦参碱在肝癌防治中的作用及其机制研究进行综述,以期为开发潜在的新型抗肿瘤药物提供理论指导。Matrine is the effective component of dried roots,plants and fruits of Kushen(Sophora flavescens ait).Pharmacological studies have found that matrine can inhibit the proliferation,invasion,migration and induce apoptosis of hepatoma cells through related proteins,signal pathways,autophagy and epithelial-mesenchymal transition,thus exerting its antagonistic effect on anti-tumor growth.Combined with the research status at home and abroad in recent years,this paper reviewed the role and mechanism of matrine in the prevention and treatment of liver cancer,in order to provide theoretical guidance for the development of potential new anti-tumor drugs.

关 键 词：苦参碱 肝癌 作用机制 研究进展 

分 类 号：R273.357[医药卫生—中西医结合]