补肾健脾生血法治疗维持性血液透析肾性贫血疗效及血常规、肾功能指标变化研究  

Effect of Tonifying Kidney,Strengthening Spleen and Promoting Blood Therapy in Renal Anemia Patients with Maintenance Hemodialysis and Changes in Blood Routine and Renal Function Indicators

作　　者：马妍 娄广亮[1] 苏瑞芳[1] 石立新 MA Yan;LOU Guangliang;SU Ruifang;SHI Lixing(Huaihe Hospital of Henan University,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学淮河医院,河南开封475000

出　　处：《中华中医药学刊》2022年第4期127-129,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2018ZX7963)。

摘　　要：目的研究补肾健脾生血法治疗维持性血液透析肾性贫血疗效及血常规、肾功能指标变化。方法选择医院2018年11月—2019年12月收治的维持性血液透析肾性贫血患者92例为研究对象,随机均分为两组,每组46例,对照组给予生血宁片治疗,观察组给予补肾健脾生血法治疗,观察比较两组的总有效率、中医症状积分、血常规、肾功能、不良反应发生情况。结果观察组总有效率为97.8%(45/46)、显著高于对照组的82.6%(38/46),差异有统计学意义(P<0.05)。治疗前两组中医症状积分比较,差异均无统计学意义(P>0.05),治疗后观察组中医症状积分显著低于对照组(P<0.05)。治疗前两组血红蛋白(Hb)、红细胞压积(HCT)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)水平差异均无统计学意义(P>0.05),治疗后观察组Hb、HCT、SF、TSAT水平均显著高于对照组(P<0.05)。治疗前两组血尿素氮(BUN)、血肌酐(SCr)、24 h尿蛋白排泄率(24 h UPE)水平差异均无统计学意义(P>0.05),治疗后观察组BUN、SCr、24 h UPE水平均显著低于对照组(P<0.05)。观察组、对照组不良反应发生率分别为6.5%(3/46)、10.9%(5/46),组间差异无统计学意义(P>0.05)。结论补肾健脾生血法治疗维持性血液透析肾性贫血疗效满意,能够显著减轻临床症状,改善患者的贫血及肾功能相关指标,并且用药安全性可靠,是可行性用药方案。Objective To study the effect of tonifying kidney,strengthening spleen and promoting blood therapy in renal anemia patients with maintenance hemodialysis and the changes in blood routine and renal function indicators.Methods Ninety-two cases of renal anemia patients with maintenance hemodialysis in the hospital from November 2018 to December 2019 were selected as the research subjects and they were randomly divided into two groups,46 patients in each group.The control group was treated with Shengxuening Tablet(生血宁片)and the observation group was treated with tonifying kidney,strengthening spleen and promoting blood therapy.The total effective rate,traditional Chinese medicine symptom score,blood routine,renal function and adverse drug reactions of two groups were compared.Results The total effective rate in the observation group was 97.8%(45/46),it was significantly higher than the control group's 82.6%(38/46),and the difference was statistically significant(P<0.05).There was no significant difference in the traditional Chinese medicine symptom scores between two groups before treatment(P>0.05),and the traditional Chinese medicine symptom scores in the observation group after treatment were significantly lower than those in the control group(P<0.05).There were no significant differences in the levels of hemoglobin(Hb),hematocrit(HCT),serum ferritin(SF)or transferrin saturation(TSAT)in two groups before treatment(P>0.05),the levels of Hb,HCT,SF and TSAT were significantly higher than those in the control group(P<0.05).There were no significant differences in blood urea nitrogen(BUN),serum creatinine(SCr)or 24 h urinary protein excretion rate(24 h UPE)between two groups before treatment(P>0.05).After treatment,the BUN,SCr and 24 h UPE levels in the observation group were significantly lower than those in the control group(P<0.05).The incidences of adverse reactions in the observation group and the control group were 6.5%(3/46)and 10.9%(5/46)respectively,and there was no significant difference between the gro

关 键 词：维持性血液透析 肾性贫血 补肾健脾生血法 生血宁 血常规 肾功能 

分 类 号：R269.925[医药卫生—中西医结合]