346例上海社区糖尿病前期人群应用中医药综合疗法的临床效果评价  

Clinical therapeutic effects of comprehensive therapy of traditional Chinese medicine on 346 pre-diabetics in a community in Shanghai

作　　者：陈清光[1] 蔡梦洁 王洁[2] 徐隽斐[1] 龚凡[1] 陶乐维[1] 徐佩英 姚政[1] 陆灏[1] CHEN Qingguang;CAI Mengjie;WANG Jie;XU Junfei;GONG Fan;TAO Lewei;XU Peiying;YAO Zheng;LU Hao(Department of Endocrinology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Endocrinology,Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201999,China)

机构地区：[1]上海中医药大学附属曙光医院内分泌科,上海201203 [2]上海中医药大学附属曙光医院宝山分院内分泌科,上海201999

出　　处：《世界临床药物》2022年第3期259-263,共5页World Clinical Drug

基　　金：上海市科委科研计划项目(17401970100、21S21900700);上海市临床重点专科(shslczdzk05401);上海市中医临床重点实验室(20DZ2272200);中医糖尿病专科联盟建设项目[ZY(2018-2020)-FWTX-4011]。

摘　　要：目的 观察中医药综合疗法干预社区糖尿病(diabetes mellitus,DM)前期人群的临床疗效。方法 采用前瞻性随机对照研究设计,按干预对象所在居委,整群随机分为治疗组(n=201,常规生活方式宣教+中医药综合疗法)及对照组(n=167,常规生活方式宣教),均干预1年,观察两组DM前期人群转归情况及糖脂代谢指标变化。结果 干预随访1年后,治疗组189例(失访12例),对照组157例(失访10例)完成随访。治疗组中80例(42.33%)转归为正常糖耐量,10例(5.29%)转归为DM;对照组中57例(36.31%)转归为正常糖耐量,22例(14.01%)转归为DM,差异均具有统计学意义(P <0.05)。干预后,治疗组空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(2-hour postprandial blood glucose,2hPG)降低(P <0.05);对照组2hPG降低(P <0.05)。与对照组相比,治疗组FBG、三酰甘油差异有统计学意义(P <0.05)。结论 中医药综合疗法可降低社区DM前期人群DM发病风险。Objective To observe the clinical effects of comprehensive therapy of traditional Chinese medicine(TCM) on the patients with diabetes mellitus(DM) in the early stage.Methods A prospective randomized controlled study design was adopted.According to the neighborhood committee of the intervention object,the group was randomly divided into treatment group(n=201,routine lifestyle education+comprehensive therapy of TCM) and control group(n=167,routine lifestyle education).All patients were intervened for one year.The prognosis and changes of glucose and lipid metabolism indexes in the two groups in the early stage of DM were observed.Results After one year of follow-up,189 cases in the treatment group(12 cases lost follow-up) and 157 cases in the control group(10 cases lost follow-up) completed the follow-up.In the treatment group,80 cases(42.33%) were converted to normal glucose tolerance and 10 cases(5.29%) were converted to DM.In the control group,57 cases(36.31%) were converted to normal glucose tolerance and 22 cases(14.01%) were converted to DM(P<0.05).After the intervention,the fasting blood glucose(FBG) and 2-hour postprandial blood glucose(2hPG) in the treatment group decreased(P<0.05).In the control group,2hPG decreased(P<0.05).Compared with the control group,the difference of FBG and triacylglycerol in the treatment group was statistically significant(P<0.05).Conclusion The comprehensive therapy of TCM can reduce the risk of DM in the early stage of DM in the community.

关 键 词：社区 糖尿病前期 中医药综合疗法 

分 类 号：R932[医药卫生—生药学] R587.1[医药卫生—药学]